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Marrow transplantation from HLA-identical siblings for treatment of aplastic anemia: is exposure to marrow donor blood products 24 hours before high-dose cyclophosphamide needed for successful engraftment?

Publication ,  Journal Article
Storb, R; Prentice, RL; Banaji, M; Witherspoon, RP; Sullivan, KM; Stewart, P; Sanders, JE; Mason, M; Doney, K; Deeg, J; Clift, RA; Buckner, CD ...
Published in: Blood
April 1983

The present study in patients with aplastic anemia was undertaken to determine whether exposure of recipients to donor blood products 24 hr before preparation with cyclophosphamide (1) enhanced the rate of sustained engraftment of marrow from HLA-identical siblings as suggested by animal experiments, (2) increased the rejection rate, in particular in transfused patients who may already have been exposed to donor antigens by blood products, or (3) was of no relevance to the outcome of transplantation of marrow from HLA-identical siblings. One-hundred fifty-five patients were studied, of whom 78 received blood products from the marrow donor 24 hr before cyclophosphamide and 77 did not. A binary logistic regression analysis was applied to the data, simultaneously considering five previously known risk factors for rejection. Results showed that preceding transfusion of donor blood products had neither a significant beneficial nor detrimental effect on the incidence of sustained engraftment.

Duke Scholars

Published In

Blood

ISSN

0006-4971

Publication Date

April 1983

Volume

61

Issue

4

Start / End Page

672 / 675

Location

United States

Related Subject Headings

  • Time Factors
  • Sibling Relations
  • Immunology
  • Humans
  • Histocompatibility
  • HLA Antigens
  • Graft Survival
  • Graft Rejection
  • Cyclophosphamide
  • Bone Marrow Transplantation
 

Citation

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Storb, R., Prentice, R. L., Banaji, M., Witherspoon, R. P., Sullivan, K. M., Stewart, P., … Thomas, E. D. (1983). Marrow transplantation from HLA-identical siblings for treatment of aplastic anemia: is exposure to marrow donor blood products 24 hours before high-dose cyclophosphamide needed for successful engraftment? Blood, 61(4), 672–675.
Storb, R., R. L. Prentice, M. Banaji, R. P. Witherspoon, K. M. Sullivan, P. Stewart, J. E. Sanders, et al. “Marrow transplantation from HLA-identical siblings for treatment of aplastic anemia: is exposure to marrow donor blood products 24 hours before high-dose cyclophosphamide needed for successful engraftment?Blood 61, no. 4 (April 1983): 672–75.
Storb R, Prentice RL, Banaji M, Witherspoon RP, Sullivan KM, Stewart P, Sanders JE, Mason M, Doney K, Deeg J, Clift RA, Buckner CD, Appelbaum FR, Thomas ED. Marrow transplantation from HLA-identical siblings for treatment of aplastic anemia: is exposure to marrow donor blood products 24 hours before high-dose cyclophosphamide needed for successful engraftment? Blood. 1983 Apr;61(4):672–675.

Published In

Blood

ISSN

0006-4971

Publication Date

April 1983

Volume

61

Issue

4

Start / End Page

672 / 675

Location

United States

Related Subject Headings

  • Time Factors
  • Sibling Relations
  • Immunology
  • Humans
  • Histocompatibility
  • HLA Antigens
  • Graft Survival
  • Graft Rejection
  • Cyclophosphamide
  • Bone Marrow Transplantation