Fanconi's anemia treated by allogeneic marrow transplantation.

Journal Article (Journal Article)

Eight patients with Fanconi's anemia were given cyclophosphamide alone (seven patients) or combined with procarbazine and antithymocyte globulin (one patient) followed by marrow grafts from HLA-identical siblings. All patients had engraftment. Seven developed acute and three chronic graft-versus-host disease (GVHD). Three patients died with GVHD and infectious complications (days 19, 56, and 82) and one with an intracerebral hemorrhage (day 540). Four patients are surviving 647-3435 days after grafting, two are well, and two have chronic GVHD that is improving. These results show that Fanconi's anemia can be treated successfully by allogeneic marrow transplantation.

Full Text

Duke Authors

Cited Authors

  • Deeg, HJ; Storb, R; Thomas, ED; Appelbaum, F; Buckner, CD; Clift, RA; Doney, K; Johnson, L; Sanders, JE; Stewart, P; Sullivan, KM; Witherspoon, RP

Published Date

  • May 1, 1983

Published In

Volume / Issue

  • 61 / 5

Start / End Page

  • 954 - 959

PubMed ID

  • 6338978

International Standard Serial Number (ISSN)

  • 0006-4971


  • eng

Conference Location

  • United States