Immunological recovery in 48 patients following syngeneic marrow transplantation for hematological malignancy

Journal Article

Opportunistic infection in syngeneic marrow graft recipients is less frequent than in allogeneic recipients. The speed and degree of immunological reconstitution may play a role in this difference. Immunological function of 48 syngeneic transplant patients prepared with 120 mg of cyclophosphamide per kg and 9.2 to 12.0 Gy (920 to 1000 rad) total body irradiation was compared with that of 153 allogeneic recipients. Lymphocyte counts and T cell numbers in syngeneic recipients were low during the first post-transplant month but higher than those of allogeneic recipients. Serum immunoglobulin levels in syngeneic recipients were normal by completion of the first post-transplantation month and were higher than allogeneic recipients at that time. Total hemolytic complement (CH50) and third (C3) and fourth (C4) components were normal throughout the post-transplantation course in both groups of patients. Antibody production to primary injection of bacteriophage θX174 (phage) was low in both syngeneic and allogeneic recipients during the first post-transplantation month and rose gradually thereafter. Some syngeneic recipients failed to produce normal amounts of IgG in their secondary response to phage. Antibody production after primary and secondary injection of keyhole limpet hemocyanin or pneumococcal polysaccharide was lower than normal early grafting and rose later, comparable to that seen in allogeneic recipients. The authors conclude that immunological recovery in syngeneic recipients is very similar to recovery in allogeneic recipients except in the first month postgrafting where twins are slightly better than allogeneic recipients for lymphocyte and immunoglobulin levels. Other mechanisms than those listed here must play an important role in protecting the syngeneic marrow graft recipient from opportunistic infection.

Duke Authors

Cited Authors

  • Witherspoon, RP; Kopecky, K; Storb, RF; Flournoy, N; Sullivan, KM; Sosa, R; Deeg, HJ; Ochs, HD; Cheever, MA; Fefer, A; Thomas, ED

Published Date

  • 1982

Published In

Volume / Issue

  • 33 / 2

Start / End Page

  • 143 - 149

PubMed ID

  • 7036468

International Standard Serial Number (ISSN)

  • 0041-1337