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Low serum thymic hormone levels in patients with chronic graft-versus-host disease.

Publication ,  Journal Article
Atkinson, K; Incefy, GS; Storb, R; Sullivan, KM; Iwata, T; Dardenne, M; Ochs, HD; Good, RA; Thomas, ED
Published in: Blood
May 1982

We tested the hypothesis that chronic graft-versus-host disease (GVHD) is due to inadequate thymic function by examining pretransplant serum levels of facteur thymique serique (FTS). Four of five patients with no detectable FTS activity developed chronic GVHD, while one of four with some FTS activity did. Further patient numbers are needed to confirm or reject this hypothesis. We further postulated that chronic GVHD, whatever its cause, involves thymic epithelium as a target organ. When tested 11 mo or more posttransplant, patients with chronic GVHD had lower absolute FTS levels (p less than 0.02) and lower age-corrected levels (p = 0.05) than patients without chronic GHVD. Low values in chronic GVHD were associated with the disease itself and not its therapy. These findings show that thymic epithelial secretory function is impaired in chronic GVHD, and this may in part be responsible for the immunodeficiency characteristic of these patients.

Duke Scholars

Published In

Blood

ISSN

0006-4971

Publication Date

May 1982

Volume

59

Issue

5

Start / End Page

1073 / 1077

Location

United States

Related Subject Headings

  • Thymus Hormones
  • Thymic Factor, Circulating
  • Male
  • Leukemia, Myeloid
  • Leukemia, Lymphoid
  • Immunology
  • Humans
  • Graft vs Host Reaction
  • Female
  • Child, Preschool
 

Citation

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Atkinson, K., Incefy, G. S., Storb, R., Sullivan, K. M., Iwata, T., Dardenne, M., … Thomas, E. D. (1982). Low serum thymic hormone levels in patients with chronic graft-versus-host disease. Blood, 59(5), 1073–1077.
Atkinson, K., G. S. Incefy, R. Storb, K. M. Sullivan, T. Iwata, M. Dardenne, H. D. Ochs, R. A. Good, and E. D. Thomas. “Low serum thymic hormone levels in patients with chronic graft-versus-host disease.Blood 59, no. 5 (May 1982): 1073–77.
Atkinson K, Incefy GS, Storb R, Sullivan KM, Iwata T, Dardenne M, et al. Low serum thymic hormone levels in patients with chronic graft-versus-host disease. Blood. 1982 May;59(5):1073–7.
Atkinson, K., et al. “Low serum thymic hormone levels in patients with chronic graft-versus-host disease.Blood, vol. 59, no. 5, May 1982, pp. 1073–77.
Atkinson K, Incefy GS, Storb R, Sullivan KM, Iwata T, Dardenne M, Ochs HD, Good RA, Thomas ED. Low serum thymic hormone levels in patients with chronic graft-versus-host disease. Blood. 1982 May;59(5):1073–1077.

Published In

Blood

ISSN

0006-4971

Publication Date

May 1982

Volume

59

Issue

5

Start / End Page

1073 / 1077

Location

United States

Related Subject Headings

  • Thymus Hormones
  • Thymic Factor, Circulating
  • Male
  • Leukemia, Myeloid
  • Leukemia, Lymphoid
  • Immunology
  • Humans
  • Graft vs Host Reaction
  • Female
  • Child, Preschool