Allogeneic marrow transplantation for acute leukemia in relapse.

Journal Article (Journal Article)

The results of allogeneic marrow transplantation in 75 patients with acute lymphoblastic leukemia and 63 patients with acute non-lymphoblastic leukemia in relapse are reviewed. The effects of various chemotherapeutic regimens added to the basic regimen of cyclophosphamide (Cy) 60 mg/kg given on each of two successive days followed by 1000 rad of total body irradiation (TBI) were evaluated. The regimens tested were dimethylbusulphan (DMB), 1,3-bis(2-chlorethyl)-1-nitrosourea (BCNU) and daunorubicin. Seventeen of 138 patients are alive between three and nine and a half years from transplantation. The addition of other chemotherapeutic agents to th basic Cy and TBI regimen did not decrease relapse frequency or prolong survival.

Full Text

Duke Authors

Cited Authors

  • Badger, C; Buckner, CD; Thomas, ED; Clift, RA; Sanders, JE; Stewart, PS; Storb, R; Sullivan, KM; Shulman, H; Flournoy, N

Published Date

  • 1982

Published In

Volume / Issue

  • 6 / 3

Start / End Page

  • 383 - 387

PubMed ID

  • 6750250

International Standard Serial Number (ISSN)

  • 0145-2126

Digital Object Identifier (DOI)

  • 10.1016/0145-2126(82)90101-1


  • eng

Conference Location

  • England