Allogeneic marrow transplantation for acute leukemia in relapse

Journal Article

The results of allogeneic marrow transplantation in 75 patients with acute lymphoblastic leukemia and 63 patients with acute non-lymphoblastic leukemia in relapse are reviewed. The effects of various chemotherapeutic regimens added to the basic regimen of cyclophosphamide (Cy) 60 mg/kg given on each of two successive days followed by 1000 rad of total body irradiation (TBI) were evaluated. The regimens tested were dimethylbusulphan (DMB), 1.3-bis(2-chlorethyl)-1-nitrosourea (BCNU) and daunorubicin. Seventeen of 138 patients are alive between three and nine and a half years from transplantation. The addition of other chemotherapeutic agents to the basic Cy and TBI regimen did not decrease relapse frequency or prolong survival. © 1982.

Duke Authors

Cited Authors

  • Badger, C; Buckner, CD; Thomas, ED; Clift, RA; Sanders, JE; Stewart, PS; Storb, R; Sullivan, KM; Shulman, H; Flournoy, N

Published Date

  • 1982

Published In

Volume / Issue

  • 6 / 3

Start / End Page

  • 383 - 387

PubMed ID

  • 6750250

International Standard Serial Number (ISSN)

  • 0145-2126