Allogeneic marrow transplantation using fractionated total body irradiation in patients with acute lymphoblastic leukemia in relapse.

Journal Article (Journal Article)

Six fractionated total body irradiation (TBI) regimens given over 2-7 days to a total midline dose of between 1200 and 1750 rads were evaluated in 41 patients with acute lymphoblastic leukemia in relapse. Cyclophosphamide 120 mg/kg was given prior to TBI in all cases, and dimethylbusulphan was added to cyclophosphamide and 1500 rad TBI in one regimen. Relapses occurred in all regimens. The overall disease-free survival of three of 41 patients was not different from previous studies with 1000 rad TBI given in a single dose. Graft-vs-host disease occurred in only 12 of 41 patients. Two of three disease-free survivors had significant graft-vs-host disease.

Full Text

Duke Authors

Cited Authors

  • Clift, RA; Buckner, CD; Thomas, ED; Sanders, JE; Stewart, PS; Sullivan, KM; McGuffin, R; Hersman, J; Sale, GE; Storb, R

Published Date

  • 1982

Published In

Volume / Issue

  • 6 / 3

Start / End Page

  • 401 - 407

PubMed ID

  • 6750253

International Standard Serial Number (ISSN)

  • 0145-2126

Digital Object Identifier (DOI)

  • 10.1016/0145-2126(82)90104-7


  • eng

Conference Location

  • England