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Allogeneic marrow transplantation using fractionated total body irradiation in patients with acute lymphoblastic leukemia in relapse.

Publication ,  Journal Article
Clift, RA; Buckner, CD; Thomas, ED; Sanders, JE; Stewart, PS; Sullivan, KM; McGuffin, R; Hersman, J; Sale, GE; Storb, R
Published in: Leuk Res
1982

Six fractionated total body irradiation (TBI) regimens given over 2-7 days to a total midline dose of between 1200 and 1750 rads were evaluated in 41 patients with acute lymphoblastic leukemia in relapse. Cyclophosphamide 120 mg/kg was given prior to TBI in all cases, and dimethylbusulphan was added to cyclophosphamide and 1500 rad TBI in one regimen. Relapses occurred in all regimens. The overall disease-free survival of three of 41 patients was not different from previous studies with 1000 rad TBI given in a single dose. Graft-vs-host disease occurred in only 12 of 41 patients. Two of three disease-free survivors had significant graft-vs-host disease.

Duke Scholars

Published In

Leuk Res

DOI

ISSN

0145-2126

Publication Date

1982

Volume

6

Issue

3

Start / End Page

401 / 407

Location

England

Related Subject Headings

  • Whole-Body Irradiation
  • Recurrence
  • Pneumonia
  • Middle Aged
  • Leukemia, Lymphoid
  • Immunology
  • Humans
  • Graft vs Host Reaction
  • Cyclophosphamide
  • Child, Preschool
 

Citation

APA
Chicago
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MLA
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Clift, R. A., Buckner, C. D., Thomas, E. D., Sanders, J. E., Stewart, P. S., Sullivan, K. M., … Storb, R. (1982). Allogeneic marrow transplantation using fractionated total body irradiation in patients with acute lymphoblastic leukemia in relapse. Leuk Res, 6(3), 401–407. https://doi.org/10.1016/0145-2126(82)90104-7
Clift, R. A., C. D. Buckner, E. D. Thomas, J. E. Sanders, P. S. Stewart, K. M. Sullivan, R. McGuffin, J. Hersman, G. E. Sale, and R. Storb. “Allogeneic marrow transplantation using fractionated total body irradiation in patients with acute lymphoblastic leukemia in relapse.Leuk Res 6, no. 3 (1982): 401–7. https://doi.org/10.1016/0145-2126(82)90104-7.
Clift RA, Buckner CD, Thomas ED, Sanders JE, Stewart PS, Sullivan KM, et al. Allogeneic marrow transplantation using fractionated total body irradiation in patients with acute lymphoblastic leukemia in relapse. Leuk Res. 1982;6(3):401–7.
Clift, R. A., et al. “Allogeneic marrow transplantation using fractionated total body irradiation in patients with acute lymphoblastic leukemia in relapse.Leuk Res, vol. 6, no. 3, 1982, pp. 401–07. Pubmed, doi:10.1016/0145-2126(82)90104-7.
Clift RA, Buckner CD, Thomas ED, Sanders JE, Stewart PS, Sullivan KM, McGuffin R, Hersman J, Sale GE, Storb R. Allogeneic marrow transplantation using fractionated total body irradiation in patients with acute lymphoblastic leukemia in relapse. Leuk Res. 1982;6(3):401–407.
Journal cover image

Published In

Leuk Res

DOI

ISSN

0145-2126

Publication Date

1982

Volume

6

Issue

3

Start / End Page

401 / 407

Location

England

Related Subject Headings

  • Whole-Body Irradiation
  • Recurrence
  • Pneumonia
  • Middle Aged
  • Leukemia, Lymphoid
  • Immunology
  • Humans
  • Graft vs Host Reaction
  • Cyclophosphamide
  • Child, Preschool