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A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A

Publication ,  Journal Article
Cruz-Migoni, A; Hautbergue, GM; Artymiuk, PJ; Baker, PJ; Bokori-Brown, M; Chang, CT; Dickman, MJ; Essex-Lopresti, A; Harding, SV; Mahadi, NM; al, E
Published in: Science
2011

The structure of BPSL1549, a protein of unknown function from Burkholderia pseudomallei, reveals a similarity to Escherichia coli cytotoxic necrotizing factor 1. We found that BPSL1549 acted as a potent cytotoxin against eukaryotic cells and was lethal when administered to mice. Expression levels of bpsl1549 correlate with conditions expected to promote or suppress pathogenicity. BPSL1549 promotes deamidation of glutamine-339 of the translation initiation factor eIF4A, abolishing its helicase activity and inhibiting translation. We propose to name BPSL1549 Burkholderia lethal factor 1.

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Published In

Science

DOI

ISSN

0036-8075

Publication Date

2011

Volume

334

Issue

6057

Start / End Page

821 / 824

Related Subject Headings

  • General Science & Technology
 

Citation

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Cruz-Migoni, A., Hautbergue, G. M., Artymiuk, P. J., Baker, P. J., Bokori-Brown, M., Chang, C. T., … al, E. (2011). A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A. Science, 334(6057), 821–824. https://doi.org/10.1126/science.1211915
Cruz-Migoni, A., G. M. Hautbergue, P. J. Artymiuk, P. J. Baker, M. Bokori-Brown, C. T. Chang, M. J. Dickman, et al. “A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A.” Science 334, no. 6057 (2011): 821–24. https://doi.org/10.1126/science.1211915.
Cruz-Migoni A, Hautbergue GM, Artymiuk PJ, Baker PJ, Bokori-Brown M, Chang CT, et al. A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A. Science. 2011;334(6057):821–4.
Cruz-Migoni, A., et al. “A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A.” Science, vol. 334, no. 6057, 2011, pp. 821–24. Scival, doi:10.1126/science.1211915.
Cruz-Migoni A, Hautbergue GM, Artymiuk PJ, Baker PJ, Bokori-Brown M, Chang CT, Dickman MJ, Essex-Lopresti A, Harding SV, Mahadi NM, al E. A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A. Science. 2011;334(6057):821–824.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

2011

Volume

334

Issue

6057

Start / End Page

821 / 824

Related Subject Headings

  • General Science & Technology