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Gut hormones, appetite suppression and cachexia in patients with pulmonary TB.

Publication ,  Journal Article
Chang, SW; Pan, WS; Lozano Beltran, D; Oleyda Baldelomar, L; Solano, MA; Tuero, I; Friedland, JS; Torrico, F; Gilman, RH
Published in: PloS one
January 2013

Cachexia is a hallmark of pulmonary tuberculosis and is associated with poor prognosis. A better understanding of the mechanisms behind such weight loss could reveal targets for therapeutic intervention. The role of appetite-regulatory hormones in tuberculosis is unknown.41 subjects with newly-diagnosed pulmonary TB (cases) were compared to 82 healthy controls. We measured appetite, body mass index (BMI), % body fat (BF), plasma peptide YY (PYY), leptin, ghrelin, and resistin for all subjects. Measurements were taken at baseline for controls and at treatment days 0, 30, and 60 for cases. Baseline appetite, BMI, and BF were lower in cases than in controls and improved during treatment. PYY, ghrelin, and resistin were significantly elevated in cases and fell during treatment. Leptin was lower in cases and rose with treatment. Appetite was inversely related to PYY in cases. High pre-treatment PYY predicted reduced gains in appetite and BF. PYY was the strongest independent predictor of appetite in cases across all time points.Appetite-regulatory hormones are altered in TB patients. As hormones normalize during treatment, appetite is restored and nutritional status improves. High baseline PYY is an indicator of poor prognosis for improvement in appetite and nutrition during treatment. Wasting in TB patients may partly be mediated by upregulation of PYY with resulting appetite suppression.

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Published In

PloS one

DOI

EISSN

1932-6203

ISSN

1932-6203

Publication Date

January 2013

Volume

8

Issue

1

Start / End Page

e54564

Related Subject Headings

  • Tuberculosis, Pulmonary
  • Nutritional Status
  • Humans
  • General Science & Technology
  • Gastrointestinal Hormones
  • Cohort Studies
  • Cachexia
  • Appetite
 

Citation

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Chicago
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MLA
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Chang, S. W., Pan, W. S., Lozano Beltran, D., Oleyda Baldelomar, L., Solano, M. A., Tuero, I., … Gilman, R. H. (2013). Gut hormones, appetite suppression and cachexia in patients with pulmonary TB. PloS One, 8(1), e54564. https://doi.org/10.1371/journal.pone.0054564
Chang, Suzanne W., William S. Pan, Daniel Lozano Beltran, Lizet Oleyda Baldelomar, Marco Antonio Solano, Iskra Tuero, Jon S. Friedland, Faustino Torrico, and Robert H. Gilman. “Gut hormones, appetite suppression and cachexia in patients with pulmonary TB.PloS One 8, no. 1 (January 2013): e54564. https://doi.org/10.1371/journal.pone.0054564.
Chang SW, Pan WS, Lozano Beltran D, Oleyda Baldelomar L, Solano MA, Tuero I, et al. Gut hormones, appetite suppression and cachexia in patients with pulmonary TB. PloS one. 2013 Jan;8(1):e54564.
Chang, Suzanne W., et al. “Gut hormones, appetite suppression and cachexia in patients with pulmonary TB.PloS One, vol. 8, no. 1, Jan. 2013, p. e54564. Epmc, doi:10.1371/journal.pone.0054564.
Chang SW, Pan WS, Lozano Beltran D, Oleyda Baldelomar L, Solano MA, Tuero I, Friedland JS, Torrico F, Gilman RH. Gut hormones, appetite suppression and cachexia in patients with pulmonary TB. PloS one. 2013 Jan;8(1):e54564.

Published In

PloS one

DOI

EISSN

1932-6203

ISSN

1932-6203

Publication Date

January 2013

Volume

8

Issue

1

Start / End Page

e54564

Related Subject Headings

  • Tuberculosis, Pulmonary
  • Nutritional Status
  • Humans
  • General Science & Technology
  • Gastrointestinal Hormones
  • Cohort Studies
  • Cachexia
  • Appetite