Laser Doppler velocimetry in retinal arteries of infants

Journal Article (Journal Article)

The present study was conducted to assess the feasibility of laser Doppler velocimetry in young infants, as a prelude to ultimately undertaking such measurements in premature infants. A portable, unidirectional laser Doppler velocimeter was developed based on a Kowa RC-2 hand-held fundus camera. Six infants between 1 and 21 weeks of age were studied. Relative red blood cell velocity (δfmax) at the centre of retinal arteries was measured over approximately 10 heart cycles. A pulsatility parameter (P=1-δfmax.dia/δfmax.sys), a summary index of vascular status, was determined from the average diastolic and systolic values of δfmax. Velocity waveforms were obtained in four of the six infants. Arterial pulsatility for the group was 0.63±0.13. Precise non-invasive measurement of arterial red blood cell velocity waveforms in young infants was achieved. The high signal-to-noise ratio and temporal resolution of this data suggest that relative measurements of retinal blood flow may permit assessment of haemodynamic changes in premature infants. © 1995 W.B. Saunders Company Ltd.

Full Text

Duke Authors

Cited Authors

  • Petrig, BL; Young, TL; Grunwald, JE; Quinn, GE; Riva, CE

Published Date

  • December 1, 1995

Published In

Volume / Issue

  • 10 / 4

Start / End Page

  • 267 - 272

Electronic International Standard Serial Number (EISSN)

  • 1435-604X

International Standard Serial Number (ISSN)

  • 0268-8921

Digital Object Identifier (DOI)

  • 10.1007/BF02133619

Citation Source

  • Scopus