Structural organization of the genes encoding human and murine FK-506-binding protein (FKBP) 13 and comparison to FKBP1

Journal Article

FK506-binding protein (FKBP) 12 and FKBP 13 are members of a family of proteins which bind the immunosuppressant drugs, FK506 and rapamycin. FKBP12 and FKBP13 are encoded by distinct genes, designated FKBP1 and FKBP2, respectively. The structure of human FKBP1 was previously characterized. We now report the genomic structure of the human and murine FKBP2 genes. Comparison of FKBP1 and FKBP2 reveals significant homology and correlation of intron positions in the C-terminal region, suggesting that these genes may have evolved from a common ancestral gene.

Full Text

Duke Authors

Cited Authors

  • Hendrickson, BA; Zhang, W; Craig, RJ; Jin, YJ; Bierer, BE; Burakoff, S; DiLella, AG

Published Date

  • 1993

Published In

  • Gene

Volume / Issue

  • 134 / 2

Start / End Page

  • 271 - 275

Digital Object Identifier (DOI)

  • 10.1016/0378-1119(93)90106-D