In vivo blood T(1) measurements at 1.5 T, 3 T, and 7 T.


Journal Article

The longitudinal relaxation time of blood is a crucial parameter for quantification of cerebral blood flow by arterial spin labeling and is one of the main determinants of the signal-to-noise ratio of the resulting perfusion maps. Whereas at low and medium magnetic field strengths (B0), its in vivo value is well established; at ultra-high field, this is still uncertain. In this study, longitudinal relaxation time of blood in the sagittal sinus was measured at 1.5 T, 3 T, and 7 T. A nonselective inversion pulse preceding a Look-Locker echo planar imaging sequence was performed to obtain the inversion recovery curve of venous blood. The results showed that longitudinal relaxation time of blood at 7 T was ∼ 2.1 s which translates to an anticipated 33% gain in the signal-to-noise ratio in arterial spin labeling experiments due to T1 relaxation alone compared with 3 T. In addition, the linear relationship between longitudinal relaxation time of blood and B0 was confirmed.

Full Text

Cited Authors

  • Zhang, X; Petersen, ET; Ghariq, E; De Vis, JB; Webb, AG; Teeuwisse, WM; Hendrikse, J; van Osch, MJP

Published Date

  • October 2013

Published In

Volume / Issue

  • 70 / 4

Start / End Page

  • 1082 - 1086

PubMed ID

  • 23172845

Pubmed Central ID

  • 23172845

Electronic International Standard Serial Number (EISSN)

  • 1522-2594

International Standard Serial Number (ISSN)

  • 0740-3194

Digital Object Identifier (DOI)

  • 10.1002/mrm.24550


  • eng