Rosiglitazone induces mitochondrial biogenesis in mouse brain.

Published

Journal Article

Rosiglitazone was found to simulate mitochondrial biogenesis in mouse brain in an apolipoprotein (Apo) E isozyme-independent manner. Rosiglitazone induced both mitochondrial DNA (mtDNA) and estrogen-stimulated related receptor alpha (ESRRA) mRNA, a key regulator of mitochondrial biogenesis. Transcriptomics and proteomics analysis suggested the mitochondria produced in the presence of human ApoE3 and E4 were not as metabolically efficient as those in the wild type or ApoE knockout mice. Thus, we propose that PPARgamma agonism induces neuronal mitochondrial biogenesis and improves glucose utilization leading to improved cellular function and provides mechanistic support for the improvement in cognition observed in treatment of Alzheimer's patients with rosiglitazone.

Full Text

Cited Authors

  • Strum, JC; Shehee, R; Virley, D; Richardson, J; Mattie, M; Selley, P; Ghosh, S; Nock, C; Saunders, A; Roses, A

Published Date

  • March 2007

Published In

Volume / Issue

  • 11 / 1

Start / End Page

  • 45 - 51

PubMed ID

  • 17361034

Pubmed Central ID

  • 17361034

Electronic International Standard Serial Number (EISSN)

  • 1875-8908

International Standard Serial Number (ISSN)

  • 1387-2877

Digital Object Identifier (DOI)

  • 10.3233/jad-2007-11108

Language

  • eng