Development of angle-resolved low coherence interferometry for clinical detection of dysplasia.

Journal Article (Journal Article)

This review covers the development of angle-resolved low coherence interferometry (a/LCI) from initial development through clinical application. In the first applications, the approach used a time-domain interferometry scheme and was validated using animal models of carcinogenesis to assess the feasibility of detecting dysplasia in situ. Further development of the approach led to Fourier-domain interferometry schemes with higher throughput and endoscope-compatible probes to enable clinical application. These later implementations have been applied to clinical studies of dysplasia in Barrett's esophagus tissues, a metaplastic tissue type that is associated with an increased risk of esophageal adenocarcinoma. As an alternative to systematic biopsy, the a/LCI approach offers high sensitivity and specificity for detecting dysplasia in these tissues while avoiding the need for tissue removal or exogenous contrast agents. Here, the various implementations of a/LCI are discussed and the results of the preliminary animal experiments and ex vivo human tissue studies are reviewed. A review of a recent in vivo clinical study is also presented.

Full Text

Duke Authors

Cited Authors

  • Zhu, Y; Terry, NG; Wax, A

Published Date

  • January 2011

Published In

Volume / Issue

  • 10 /

Start / End Page

  • 19 -

PubMed ID

  • 21886457

Pubmed Central ID

  • PMC3162729

Electronic International Standard Serial Number (EISSN)

  • 1477-3163

International Standard Serial Number (ISSN)

  • 1477-3163

Digital Object Identifier (DOI)

  • 10.4103/1477-3163.83935


  • eng