NGF is essential for hippocampal plasticity and learning.

Published

Journal Article

Nerve growth factor (NGF) is produced in the hippocampus throughout life and is retrogradely trafficked to septal cholinergic neurons, providing a potential mechanism for modulating cholinergic inputs and, thereby, hippocampal plasticity. To explore NGF modulation of hippocampal plasticity and function, NGF levels were augmented or blocked in intact adult rats, and subsequent in vivo effects on cholinergic neurons, hippocampal long-term potentiation (LTP), and learning were examined. NGF augmentation significantly enhanced cholinergic neuronal markers and facilitated induction of hippocampal LTP. Blockade of endogenous NGF significantly reduced hippocampal LTP and impaired retention of spatial memory. These findings reveal an essential role for NGF in regulating biological mechanisms related to plasticity and memory in the intact adult brain.

Full Text

Duke Authors

Cited Authors

  • Conner, JM; Franks, KM; Titterness, AK; Russell, K; Merrill, DA; Christie, BR; Sejnowski, TJ; Tuszynski, MH

Published Date

  • September 2009

Published In

Volume / Issue

  • 29 / 35

Start / End Page

  • 10883 - 10889

PubMed ID

  • 19726646

Pubmed Central ID

  • 19726646

Electronic International Standard Serial Number (EISSN)

  • 1529-2401

International Standard Serial Number (ISSN)

  • 0270-6474

Digital Object Identifier (DOI)

  • 10.1523/JNEUROSCI.2594-09.2009

Language

  • eng