Mice with a "monoclonal nose": perturbations in an olfactory map impair odor discrimination.

Journal Article (Journal Article)

We have altered the neural representation of odors in the brain by generating a mouse with a "monoclonal nose" in which greater than 95% of the sensory neurons express a single odorant receptor, M71. As a consequence, the frequency of sensory neurons expressing endogenous receptor genes is reduced 20-fold. We observe that these mice can smell, but odor discrimination and performance in associative olfactory learning tasks are impaired. However, these mice cannot detect the M71 ligand acetophenone despite the observation that virtually all sensory neurons and glomeruli are activated by this odor. The M71 transgenic mice readily detect other odors in the presence of acetophenone. These observations have implications for how receptor activation in the periphery is represented in the brain and how these representations encode odors.

Full Text

Duke Authors

Cited Authors

  • Fleischmann, A; Shykind, BM; Sosulski, DL; Franks, KM; Glinka, ME; Mei, DF; Sun, Y; Kirkland, J; Mendelsohn, M; Albers, MW; Axel, R

Published Date

  • December 26, 2008

Published In

Volume / Issue

  • 60 / 6

Start / End Page

  • 1068 - 1081

PubMed ID

  • 19109912

Pubmed Central ID

  • PMC2732586

Electronic International Standard Serial Number (EISSN)

  • 1097-4199

Digital Object Identifier (DOI)

  • 10.1016/j.neuron.2008.10.046


  • eng

Conference Location

  • United States