Skip to main content
Journal cover image

Mice with a "monoclonal nose": perturbations in an olfactory map impair odor discrimination.

Publication ,  Journal Article
Fleischmann, A; Shykind, BM; Sosulski, DL; Franks, KM; Glinka, ME; Mei, DF; Sun, Y; Kirkland, J; Mendelsohn, M; Albers, MW; Axel, R
Published in: Neuron
December 26, 2008

We have altered the neural representation of odors in the brain by generating a mouse with a "monoclonal nose" in which greater than 95% of the sensory neurons express a single odorant receptor, M71. As a consequence, the frequency of sensory neurons expressing endogenous receptor genes is reduced 20-fold. We observe that these mice can smell, but odor discrimination and performance in associative olfactory learning tasks are impaired. However, these mice cannot detect the M71 ligand acetophenone despite the observation that virtually all sensory neurons and glomeruli are activated by this odor. The M71 transgenic mice readily detect other odors in the presence of acetophenone. These observations have implications for how receptor activation in the periphery is represented in the brain and how these representations encode odors.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

December 26, 2008

Volume

60

Issue

6

Start / End Page

1068 / 1081

Location

United States

Related Subject Headings

  • Sexual Behavior, Animal
  • Receptors, Odorant
  • Olfactory Receptor Neurons
  • Olfactory Pathways
  • Olfactory Bulb
  • Olfaction Disorders
  • Odorants
  • Nose
  • Neurology & Neurosurgery
  • Mice, Transgenic
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Fleischmann, A., Shykind, B. M., Sosulski, D. L., Franks, K. M., Glinka, M. E., Mei, D. F., … Axel, R. (2008). Mice with a "monoclonal nose": perturbations in an olfactory map impair odor discrimination. Neuron, 60(6), 1068–1081. https://doi.org/10.1016/j.neuron.2008.10.046
Fleischmann, Alexander, Benjamin M. Shykind, Dara L. Sosulski, Kevin M. Franks, Meredith E. Glinka, Dan Feng Mei, Yonghua Sun, et al. “Mice with a "monoclonal nose": perturbations in an olfactory map impair odor discrimination.Neuron 60, no. 6 (December 26, 2008): 1068–81. https://doi.org/10.1016/j.neuron.2008.10.046.
Fleischmann A, Shykind BM, Sosulski DL, Franks KM, Glinka ME, Mei DF, et al. Mice with a "monoclonal nose": perturbations in an olfactory map impair odor discrimination. Neuron. 2008 Dec 26;60(6):1068–81.
Fleischmann, Alexander, et al. “Mice with a "monoclonal nose": perturbations in an olfactory map impair odor discrimination.Neuron, vol. 60, no. 6, Dec. 2008, pp. 1068–81. Pubmed, doi:10.1016/j.neuron.2008.10.046.
Fleischmann A, Shykind BM, Sosulski DL, Franks KM, Glinka ME, Mei DF, Sun Y, Kirkland J, Mendelsohn M, Albers MW, Axel R. Mice with a "monoclonal nose": perturbations in an olfactory map impair odor discrimination. Neuron. 2008 Dec 26;60(6):1068–1081.
Journal cover image

Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

December 26, 2008

Volume

60

Issue

6

Start / End Page

1068 / 1081

Location

United States

Related Subject Headings

  • Sexual Behavior, Animal
  • Receptors, Odorant
  • Olfactory Receptor Neurons
  • Olfactory Pathways
  • Olfactory Bulb
  • Olfaction Disorders
  • Odorants
  • Nose
  • Neurology & Neurosurgery
  • Mice, Transgenic