An MCell model of calcium dynamics and frequency-dependence of calmodulin activation in dendritic spines

Journal Article (Journal Article)

Pairing action potentials in synaptically coupled cortical pyramidal cells induces LTP in a frequency-dependent manner (H. Markram et al., Science 275 (1997) 213). Using Mcell, which simulated the 3D geometry of the spine and the diffusion and binding of Ca 2+, we show that pairing five EPSPs and back-propagating action potentials results in a Ca 2+ influx into a model dendritic spine that is largely frequency independent but leads to a frequency-dependent activation of postsynaptic calmodulin. Furthermore, we show how altering the availability of calmodulin and the calcium-binding capacity can alter the efficacy and potency of the frequency-response curve. The model shows how the cell can regulate its plasticity by buffering Ca 2+ signals. © 2001 Elsevier Science B.V. All rights reserved.

Full Text

Duke Authors

Cited Authors

  • Franks, KM; Bartol, TM; Sejnowski, TJ

Published Date

  • June 1, 2001

Published In

Volume / Issue

  • 38-40 /

Start / End Page

  • 9 - 16

International Standard Serial Number (ISSN)

  • 0925-2312

Digital Object Identifier (DOI)

  • 10.1016/S0925-2312(01)00415-5

Citation Source

  • Scopus