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Neurod6 expression defines new retinal amacrine cell subtypes and regulates their fate.

Publication ,  Journal Article
Kay, JN; Voinescu, PE; Chu, MW; Sanes, JR
Published in: Nat Neurosci
July 10, 2011

Most regions of the CNS contain many subtypes of inhibitory interneurons with specialized roles in circuit function. In the mammalian retina, the ∼30 subtypes of inhibitory interneurons called amacrine cells (ACs) are generally divided into two groups: wide/medium-field GABAergic ACs and narrow-field glycinergic ACs, which mediate lateral and vertical interactions, respectively, within the inner plexiform layer. We used expression profiling and mouse transgenic lines to identify and characterize two closely related narrow-field AC subtypes. Both arise postnatally and one is neither glycinergic nor GABAergic (nGnG). Two transcription factors selectively expressed by these subtypes, Neurod6 and special AT-rich-sequence-binding protein 2 (Satb2), regulate a postmitotic cell fate choice between these subtypes. Satb2 induces Neurod6, which persists in nGnG ACs and promotes their fate but is downregulated in the related glycinergic AC subtype. Our results support the view that cell fate decisions made in progenitors and their progeny act together to diversify ACs.

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Published In

Nat Neurosci

DOI

EISSN

1546-1726

Publication Date

July 10, 2011

Volume

14

Issue

8

Start / End Page

965 / 972

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Transcription Factors
  • Shiga Toxin 1
  • Retina
  • Neurology & Neurosurgery
  • Nerve Tissue Proteins
  • Mice, Transgenic
  • Mice, Inbred C57BL
  • Mice
  • Matrix Attachment Region Binding Proteins
 

Citation

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Kay, J. N., Voinescu, P. E., Chu, M. W., & Sanes, J. R. (2011). Neurod6 expression defines new retinal amacrine cell subtypes and regulates their fate. Nat Neurosci, 14(8), 965–972. https://doi.org/10.1038/nn.2859
Kay, Jeremy N., P Emanuela Voinescu, Monica W. Chu, and Joshua R. Sanes. “Neurod6 expression defines new retinal amacrine cell subtypes and regulates their fate.Nat Neurosci 14, no. 8 (July 10, 2011): 965–72. https://doi.org/10.1038/nn.2859.
Kay JN, Voinescu PE, Chu MW, Sanes JR. Neurod6 expression defines new retinal amacrine cell subtypes and regulates their fate. Nat Neurosci. 2011 Jul 10;14(8):965–72.
Kay, Jeremy N., et al. “Neurod6 expression defines new retinal amacrine cell subtypes and regulates their fate.Nat Neurosci, vol. 14, no. 8, July 2011, pp. 965–72. Pubmed, doi:10.1038/nn.2859.
Kay JN, Voinescu PE, Chu MW, Sanes JR. Neurod6 expression defines new retinal amacrine cell subtypes and regulates their fate. Nat Neurosci. 2011 Jul 10;14(8):965–972.

Published In

Nat Neurosci

DOI

EISSN

1546-1726

Publication Date

July 10, 2011

Volume

14

Issue

8

Start / End Page

965 / 972

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Transcription Factors
  • Shiga Toxin 1
  • Retina
  • Neurology & Neurosurgery
  • Nerve Tissue Proteins
  • Mice, Transgenic
  • Mice, Inbred C57BL
  • Mice
  • Matrix Attachment Region Binding Proteins