Handheld point-of-care cerebrospinal fluid lactate testing predicts bacterial meningitis in Uganda.


Journal Article

We validated a handheld point-of-care lactate (POCL) monitor's ability to measure lactate in cerebrospinal fluid (CSF) and diagnose bacterial meningitis in Uganda. There was a strong linear correspondence between POCL and standard laboratory lactate test results (R(2) = 0.86; P < 0.001). For 145 patients with clinical meningitis, the area under the receiver operating characteristic curve for the prediction of bacterial meningitis by CSF POCL was 0.92 (95% confidence interval = 0.85-0.99, P < 0.001). A CSF POCL concentration of 7.7 mmol/L provided 88% sensitivity and 90% specificity for the diagnosis of bacterial meningitis. CSF POCL testing had excellent use in the diagnosis of bacterial meningitis, and it may be useful where CSF analyses are delayed or laboratory infrastructure is limited.

Full Text

Cited Authors

  • Majwala, A; Burke, R; Patterson, W; Pinkerton, R; Muzoora, C; Wilson, LA; Moore, CC

Published Date

  • January 2013

Published In

Volume / Issue

  • 88 / 1

Start / End Page

  • 127 - 131

PubMed ID

  • 23243109

Pubmed Central ID

  • 23243109

Electronic International Standard Serial Number (EISSN)

  • 1476-1645

International Standard Serial Number (ISSN)

  • 0002-9637

Digital Object Identifier (DOI)

  • 10.4269/ajtmh.2012.12-0447


  • eng