Cytologic findings of gastric schwannoma: a case report.


Journal Article

Spindle cell lesions of the stomach are rare. They usually affect the submucosa or muscularis propria and therefore can be sampled by endoscopic fine needle aspiration. The most common tumor in this category is gastrointestinal stromal tumor (GIST), followed by leiomyoma and gastric schwannoma. Gastric schwannoma is a benign tumor of neuroectodermal origin that has overlapping morphologic/cytologic features with GIST and leiomyoma. Gastric schwannomas differ from peripheral schwannomas by lacking a capsule, Verocay bodies, Antoni B areas, and thick-walled vessels. They are characterized morphologically by poorly defined borders, cuffs of lymphoid tissue and a haphazard spindle cell proliferation. We present here the cytologic and histopathologic features of a gastric schwannoma. The tumor was composed of spindle cells with delicate eosinophilic cytoplasm and wavy nuclei, with an associated conspicuous lymphoid backdrop. The latter feature raised the possibility of a lymphoid lesion, a problem cytopathologists should be aware of.

Full Text

Duke Authors

Cited Authors

  • Rodriguez, E; Tellschow, S; Steinberg, DM; Montgomery, E

Published Date

  • February 2014

Published In

Volume / Issue

  • 42 / 2

Start / End Page

  • 177 - 180

PubMed ID

  • 24436245

Pubmed Central ID

  • 24436245

Electronic International Standard Serial Number (EISSN)

  • 1097-0339

Digital Object Identifier (DOI)

  • 10.1002/dc.22913


  • eng

Conference Location

  • United States