Requirement of Ca2+ for aflatoxin production: inhibitory effect of Ca2+ channel blockers on aflatoxin production by Aspergillus parasiticus NRRL 2999.

Journal Article (Journal Article)

Aflatoxin production by Aspergillus parasiticus NRRL 2999 was inhibited when Ca2+ channel blockers, i.e., verapamil and diltiazem (> 1 mmol 1(-1)), were included in the culture medium. Inhibition was not accompanied by growth inhibition, nor was the [14C]-glucose uptake by the organism altered. However, both the compounds inhibited [14C]-acetate incorporation into aflatoxin B1 in a dose-dependent manner and decreased sporulation of the organism. Even though a nutritional role for Ca2+ has not been demonstrated unequivocally in fungi, the present study suggests the importance of Ca2+ in the production of these secondary metabolites.

Full Text

Duke Authors

Cited Authors

  • Praveen Rao, J; Subramanyam, C

Published Date

  • January 1999

Published In

Volume / Issue

  • 28 / 1

Start / End Page

  • 85 - 88

PubMed ID

  • 10200037

International Standard Serial Number (ISSN)

  • 0266-8254

Digital Object Identifier (DOI)

  • 10.1046/j.1365-2672.1999.00460.x


  • eng

Conference Location

  • England