Requirement of Ca2+ for aflatoxin production: inhibitory effect of Ca2+ channel blockers on aflatoxin production by Aspergillus parasiticus NRRL 2999.
Journal Article
Aflatoxin production by Aspergillus parasiticus NRRL 2999 was inhibited when Ca2+ channel blockers, i.e., verapamil and diltiazem (> 1 mmol 1(-1)), were included in the culture medium. Inhibition was not accompanied by growth inhibition, nor was the [14C]-glucose uptake by the organism altered. However, both the compounds inhibited [14C]-acetate incorporation into aflatoxin B1 in a dose-dependent manner and decreased sporulation of the organism. Even though a nutritional role for Ca2+ has not been demonstrated unequivocally in fungi, the present study suggests the importance of Ca2+ in the production of these secondary metabolites.
Full Text
Duke Authors
Cited Authors
- Praveen Rao, J; Subramanyam, C
Published Date
- January 1999
Published In
Volume / Issue
- 28 / 1
Start / End Page
- 85 - 88
PubMed ID
- 10200037
Pubmed Central ID
- 10200037
International Standard Serial Number (ISSN)
- 0266-8254
Digital Object Identifier (DOI)
- 10.1046/j.1365-2672.1999.00460.x
Language
- eng
Conference Location
- England