Aggressive peripheral CD70-positive T-cell lymphoma associated with severe chronic active EBV infection.


Journal Article

Severe chronic active Epstein-Barr virus infection (CAEBV) in T or NK cells is a rare complication of latent EBV infection. CAEBV associated T-cell lymphoproliferative disease (LPD) consists of polyclonal lesions as well as aggressive lymphomas. Here, we report such a patient. In addition, we show that this primary CAEBV associated T-cell lymphoma expresses CD70 and is sensitive to killing by CD70-specific T cells, identifying CD70 as a potential immunotherapeutic target for CAEBV-associated T-cell lymphoma.

Full Text

Cited Authors

  • Shaffer, DR; Sheehan, AM; Yi, Z; Rodgers, CC; Bollard, CM; Brenner, MK; Rooney, CM; Heslop, HE; Gottschalk, S

Published Date

  • October 2012

Published In

Volume / Issue

  • 59 / 4

Start / End Page

  • 758 - 761

PubMed ID

  • 21994111

Pubmed Central ID

  • 21994111

Electronic International Standard Serial Number (EISSN)

  • 1545-5017

International Standard Serial Number (ISSN)

  • 1545-5009

Digital Object Identifier (DOI)

  • 10.1002/pbc.23352


  • eng