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Treatment and outcomes of epithelioid sarcoma of the spine.

Publication ,  Journal Article
Babu, R; Karikari, IO; Cummings, TJ; Gottfried, ON; Bagley, CA
Published in: J Clin Neurosci
October 2013

Epithelioid sarcoma (ES) is a rare soft-tissue neoplasm which is most commonly found in the extremities of young adult males. ES has a poor prognosis due to its aggressiveness as it frequently recurs locally and can undergo lymphatic metastasis to soft tissue, fascia, bone, lymph nodes, lung, and brain. The most common form is the classic-type (granuloma-like), though a more aggressive subtype known as the proximal- or axial-type has also been described. As ES of the spine is exceedingly rare, with only seven patients being reported in the literature, the outcomes of these patients is unclear. We have reviewed the literature of all existing spinal ES cases to recommend treatment strategies and report the first case of proximal-type ES in the cervical spine. Patients with spinal ES had an average age of 20.7 years, with 71.4% of cases being in males. Metastasis was common and was found in 83.3% of patients, with lung metastasis being found in 60% of these patients. Due to the high rates of local recurrence and distant metastasis, the goal of surgery remains gross total resection of all tumor and involved bony elements if feasible without significant neurological deficits. Ligation of involved nerve roots may be necessary to achieve adequate resection of the tumor mass as nerve sheaths can serve as a pathway for extension. In the cervical spine, resection of these lesions is difficult due to involvement of the vertebral arteries in addition to nerve roots, increasing the surgical risk.

Duke Scholars

Published In

J Clin Neurosci

DOI

EISSN

1532-2653

Publication Date

October 2013

Volume

20

Issue

10

Start / End Page

1342 / 1345

Location

Scotland

Related Subject Headings

  • Treatment Outcome
  • Spinal Neoplasms
  • Sarcoma
  • Neurology & Neurosurgery
  • Humans
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Babu, R., Karikari, I. O., Cummings, T. J., Gottfried, O. N., & Bagley, C. A. (2013). Treatment and outcomes of epithelioid sarcoma of the spine. J Clin Neurosci, 20(10), 1342–1345. https://doi.org/10.1016/j.jocn.2012.12.009
Babu, Ranjith, Isaac O. Karikari, Thomas J. Cummings, Oren N. Gottfried, and Carlos A. Bagley. “Treatment and outcomes of epithelioid sarcoma of the spine.J Clin Neurosci 20, no. 10 (October 2013): 1342–45. https://doi.org/10.1016/j.jocn.2012.12.009.
Babu R, Karikari IO, Cummings TJ, Gottfried ON, Bagley CA. Treatment and outcomes of epithelioid sarcoma of the spine. J Clin Neurosci. 2013 Oct;20(10):1342–5.
Babu, Ranjith, et al. “Treatment and outcomes of epithelioid sarcoma of the spine.J Clin Neurosci, vol. 20, no. 10, Oct. 2013, pp. 1342–45. Pubmed, doi:10.1016/j.jocn.2012.12.009.
Babu R, Karikari IO, Cummings TJ, Gottfried ON, Bagley CA. Treatment and outcomes of epithelioid sarcoma of the spine. J Clin Neurosci. 2013 Oct;20(10):1342–1345.
Journal cover image

Published In

J Clin Neurosci

DOI

EISSN

1532-2653

Publication Date

October 2013

Volume

20

Issue

10

Start / End Page

1342 / 1345

Location

Scotland

Related Subject Headings

  • Treatment Outcome
  • Spinal Neoplasms
  • Sarcoma
  • Neurology & Neurosurgery
  • Humans
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences