Integrated genomic characterization of endometrial carcinoma.
We performed an integrated genomic, transcriptomic and proteomic characterization of 373 endometrial carcinomas using array- and sequencing-based technologies. Uterine serous tumours and ∼25% of high-grade endometrioid tumours had extensive copy number alterations, few DNA methylation changes, low oestrogen receptor/progesterone receptor levels, and frequent TP53 mutations. Most endometrioid tumours had few copy number alterations or TP53 mutations, but frequent mutations in PTEN, CTNNB1, PIK3CA, ARID1A and KRAS and novel mutations in the SWI/SNF chromatin remodelling complex gene ARID5B. A subset of endometrioid tumours that we identified had a markedly increased transversion mutation frequency and newly identified hotspot mutations in POLE. Our results classified endometrial cancers into four categories: POLE ultramutated, microsatellite instability hypermutated, copy-number low, and copy-number high. Uterine serous carcinomas share genomic features with ovarian serous and basal-like breast carcinomas. We demonstrated that the genomic features of endometrial carcinomas permit a reclassification that may affect post-surgical adjuvant treatment for women with aggressive tumours.
Duke Scholars
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Related Subject Headings
- Transcription Factors
- Signal Transduction
- Poly-ADP-Ribose Binding Proteins
- Ovarian Neoplasms
- Humans
- Genomics
- Genome, Human
- General Science & Technology
- Gene Expression Regulation, Neoplastic
- Female
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Transcription Factors
- Signal Transduction
- Poly-ADP-Ribose Binding Proteins
- Ovarian Neoplasms
- Humans
- Genomics
- Genome, Human
- General Science & Technology
- Gene Expression Regulation, Neoplastic
- Female