Chlamydial intracellular survival strategies.

Journal Article (Journal Article;Review)

Chlamydia trachomatis is the most common sexually transmitted bacterial pathogen and the causative agent of blinding trachoma. Although Chlamydia is protected from humoral immune responses by residing within remodeled intracellular vacuoles, it still must contend with multilayered intracellular innate immune defenses deployed by its host while scavenging for nutrients. Here we provide an overview of Chlamydia biology and highlight recent findings detailing how this vacuole-bound pathogen manipulates host-cellular functions to invade host cells and maintain a replicative niche.

Full Text

Duke Authors

Cited Authors

  • Bastidas, RJ; Elwell, CA; Engel, JN; Valdivia, RH

Published Date

  • May 1, 2013

Published In

Volume / Issue

  • 3 / 5

Start / End Page

  • a010256 -

PubMed ID

  • 23637308

Pubmed Central ID

  • PMC3633179

Electronic International Standard Serial Number (EISSN)

  • 2157-1422

Digital Object Identifier (DOI)

  • 10.1101/cshperspect.a010256


  • eng

Conference Location

  • United States