Cortico-cortical projections in mouse visual cortex are functionally target specific.
Journal Article (Journal Article)
Neurons in primary sensory cortex have diverse response properties, whereas higher cortical areas are specialized. Specific connectivity may be important for areal specialization, particularly in the mouse, where neighboring neurons are functionally diverse. To examine whether higher visual areas receive functionally specific input from primary visual cortex (V1), we used two-photon calcium imaging to measure responses of axons from V1 arborizing in three areas with distinct spatial and temporal frequency preferences. We found that visual preferences of presynaptic boutons in each area were distinct and matched the average preferences of recipient neurons. This specificity could not be explained by organization within V1 and instead was due to both a greater density and greater response amplitude of functionally matched boutons. Projections from a single layer (layer 5) and from secondary visual cortex were also matched to their target areas. Thus, transmission of specific information to downstream targets may be a general feature of cortico-cortical communication.
Full Text
Duke Authors
Cited Authors
- Glickfeld, LL; Andermann, ML; Bonin, V; Reid, RC
Published Date
- February 2013
Published In
Volume / Issue
- 16 / 2
Start / End Page
- 219 - 226
PubMed ID
- 23292681
Pubmed Central ID
- PMC3808876
Electronic International Standard Serial Number (EISSN)
- 1546-1726
Digital Object Identifier (DOI)
- 10.1038/nn.3300
Language
- eng
Conference Location
- United States