Functional specialization of mouse higher visual cortical areas.
Journal Article (Journal Article)
The mouse is emerging as an important model for understanding how sensory neocortex extracts cues to guide behavior, yet little is known about how these cues are processed beyond primary cortical areas. Here, we used two-photon calcium imaging in awake mice to compare visual responses in primary visual cortex (V1) and in two downstream target areas, AL and PM. Neighboring V1 neurons had diverse stimulus preferences spanning five octaves in spatial and temporal frequency. By contrast, AL and PM neurons responded best to distinct ranges of stimulus parameters. Most strikingly, AL neurons preferred fast-moving stimuli while PM neurons preferred slow-moving stimuli. By contrast, neurons in V1, AL, and PM demonstrated similar selectivity for stimulus orientation but not for stimulus direction. Based on these findings, we predict that area AL helps guide behaviors involving fast-moving stimuli (e.g., optic flow), while area PM helps guide behaviors involving slow-moving objects.
Full Text
Duke Authors
Cited Authors
- Andermann, ML; Kerlin, AM; Roumis, DK; Glickfeld, LL; Reid, RC
Published Date
- December 22, 2011
Published In
Volume / Issue
- 72 / 6
Start / End Page
- 1025 - 1039
PubMed ID
- 22196337
Pubmed Central ID
- PMC3876958
Electronic International Standard Serial Number (EISSN)
- 1097-4199
Digital Object Identifier (DOI)
- 10.1016/j.neuron.2011.11.013
Language
- eng
Conference Location
- United States