Interneurons hyperpolarize pyramidal cells along their entire somatodendritic axis.
Journal Article (Journal Article)
Although GABAergic interneurons are the main source of synaptic inhibition in the cortex, activation of GABA(A) receptors has been shown to depolarize specific neuronal compartments, resulting in excitation. By using a noninvasive approach to monitor the effect of individual interneurons on the pyramidal cell population, we found that rat hippocampal interneurons hyperpolarized pyramidal cells irrespective of the location of their synapses along the somato-dendritic axis.
Full Text
Duke Authors
Cited Authors
- Glickfeld, LL; Roberts, JD; Somogyi, P; Scanziani, M
Published Date
- January 2009
Published In
Volume / Issue
- 12 / 1
Start / End Page
- 21 - 23
PubMed ID
- 19029887
Pubmed Central ID
- PMC3505023
Electronic International Standard Serial Number (EISSN)
- 1546-1726
Digital Object Identifier (DOI)
- 10.1038/nn.2230
Language
- eng
Conference Location
- United States