Interneurons hyperpolarize pyramidal cells along their entire somatodendritic axis.

Journal Article (Journal Article)

Although GABAergic interneurons are the main source of synaptic inhibition in the cortex, activation of GABA(A) receptors has been shown to depolarize specific neuronal compartments, resulting in excitation. By using a noninvasive approach to monitor the effect of individual interneurons on the pyramidal cell population, we found that rat hippocampal interneurons hyperpolarized pyramidal cells irrespective of the location of their synapses along the somato-dendritic axis.

Full Text

Duke Authors

Cited Authors

  • Glickfeld, LL; Roberts, JD; Somogyi, P; Scanziani, M

Published Date

  • January 2009

Published In

Volume / Issue

  • 12 / 1

Start / End Page

  • 21 - 23

PubMed ID

  • 19029887

Pubmed Central ID

  • PMC3505023

Electronic International Standard Serial Number (EISSN)

  • 1546-1726

Digital Object Identifier (DOI)

  • 10.1038/nn.2230


  • eng

Conference Location

  • United States