A network-heuristic approach to improve the impact of genomic data on drug discovery.

Journal Article (Journal Article)

The explosive growth of molecular diagnostic tests introduces the possibility of increasing our understanding of disease mechanisms in the clinic and promises to improve target identification for new therapies. A new paradigm is emerging in drug discovery that is driven by these clinically derived data. Unfortunately, the translation of novel insights into useful therapies remains costly and difficult. New clinical trial design and open validation of markers may reduce these barriers to clinical utility.

Full Text

Duke Authors

Cited Authors

  • Trister, AD; Huang, ES

Published Date

  • April 2013

Published In

Volume / Issue

  • 93 / 4

Start / End Page

  • 295 - 297

PubMed ID

  • 23511782

Electronic International Standard Serial Number (EISSN)

  • 1532-6535

Digital Object Identifier (DOI)

  • 10.1038/clpt.2012.246

Language

  • eng

Conference Location

  • United States