Barriers to preclinical investigations of anti-dengue immunity and dengue pathogenesis.
Journal Article (Review)
Dengue virus (DENV) is a human pathogen that causes severe and potentially fatal disease in millions of individuals each year. Immune-mediated pathology is thought to underlie many of the complications of DENV infection in humans, but the notable limitations of the available animal models have impeded our knowledge of the interactions between DENV and the immune system. In this Opinion article, we discuss some of the controversies in the field of dengue research relating to the interaction between DENV and the mammalian host. We highlight key barriers hindering our understanding of the molecular pathogenesis of DENV and offer suggestions for the most effective ways in which the role of the immune system in the protection from, and pathology of, DENV infection can be addressed experimentally.
Full Text
Duke Authors
Cited Authors
- St John, AL; Abraham, SN; Gubler, DJ
Published Date
- June 2013
Published In
Volume / Issue
- 11 / 6
Start / End Page
- 420 - 426
PubMed ID
- 23652323
Electronic International Standard Serial Number (EISSN)
- 1740-1534
Digital Object Identifier (DOI)
- 10.1038/nrmicro3030
Language
- eng
Conference Location
- England