Prediction of a time-to-event trait using genome wide SNP data.

Published online

Journal Article

BACKGROUND: A popular objective of many high-throughput genome projects is to discover various genomic markers associated with traits and develop statistical models to predict traits of future patients based on marker values. RESULTS: In this paper, we present a prediction method for time-to-event traits using genome-wide single-nucleotide polymorphisms (SNPs). We also propose a MaxTest associating between a time-to-event trait and a SNP accounting for its possible genetic models. The proposed MaxTest can help screen out nonprognostic SNPs and identify genetic models of prognostic SNPs. The performance of the proposed method is evaluated through simulations. CONCLUSIONS: In conjunction with the MaxTest, the proposed method provides more parsimonious prediction models but includes more prognostic SNPs than some naive prediction methods. The proposed method is demonstrated with real GWAS data.

Full Text

Duke Authors

Cited Authors

  • Kim, J; Sohn, I; Son, D-S; Kim, DH; Ahn, T; Jung, S-H

Published Date

  • February 19, 2013

Published In

Volume / Issue

  • 14 /

Start / End Page

  • 58 -

PubMed ID

  • 23418752

Electronic International Standard Serial Number (EISSN)

  • 1471-2105

Digital Object Identifier (DOI)

  • 10.1186/1471-2105-14-58

Language

  • eng

Conference Location

  • England