Diagnosis and management of heparin-induced thrombocytopenia.
Publication
, Journal Article
Lee, GM; Arepally, GM
Published in: Hematol Oncol Clin North Am
June 2013
Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder caused by antibodies to platelet factor 4/heparin (PF4/H) complexes. It presents with declining platelet counts 5 to 14 days after heparin administration and results in a predisposition to arterial and venous thrombosis. Establishing the diagnosis of HIT can be extremely challenging. It is essential to conduct a thorough clinical evaluation in addition to laboratory testing to confirm the presence of PF4/H antibodies. Multiple clinical algorithms have been developed to aid the clinician in predicting the likelihood of HIT. Once HIT is recognized, an alternative anticoagulant should be initiated to prevent further complications.
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Published In
Hematol Oncol Clin North Am
DOI
EISSN
1558-1977
Publication Date
June 2013
Volume
27
Issue
3
Start / End Page
541 / 563
Location
United States
Related Subject Headings
- Thrombocytopenia
- Oncology & Carcinogenesis
- Humans
- Heparin
- Algorithms
- 3201 Cardiovascular medicine and haematology
- 1102 Cardiorespiratory Medicine and Haematology
Citation
APA
Chicago
ICMJE
MLA
NLM
Lee, G. M., & Arepally, G. M. (2013). Diagnosis and management of heparin-induced thrombocytopenia. Hematol Oncol Clin North Am, 27(3), 541–563. https://doi.org/10.1016/j.hoc.2013.02.001
Lee, Grace M., and Gowthami M. Arepally. “Diagnosis and management of heparin-induced thrombocytopenia.” Hematol Oncol Clin North Am 27, no. 3 (June 2013): 541–63. https://doi.org/10.1016/j.hoc.2013.02.001.
Lee GM, Arepally GM. Diagnosis and management of heparin-induced thrombocytopenia. Hematol Oncol Clin North Am. 2013 Jun;27(3):541–63.
Lee, Grace M., and Gowthami M. Arepally. “Diagnosis and management of heparin-induced thrombocytopenia.” Hematol Oncol Clin North Am, vol. 27, no. 3, June 2013, pp. 541–63. Pubmed, doi:10.1016/j.hoc.2013.02.001.
Lee GM, Arepally GM. Diagnosis and management of heparin-induced thrombocytopenia. Hematol Oncol Clin North Am. 2013 Jun;27(3):541–563.
Published In
Hematol Oncol Clin North Am
DOI
EISSN
1558-1977
Publication Date
June 2013
Volume
27
Issue
3
Start / End Page
541 / 563
Location
United States
Related Subject Headings
- Thrombocytopenia
- Oncology & Carcinogenesis
- Humans
- Heparin
- Algorithms
- 3201 Cardiovascular medicine and haematology
- 1102 Cardiorespiratory Medicine and Haematology