Effects of Y27632 on keratinocyte procurement and wound healing.

Journal Article (Journal Article)

A number of Rho-kinase inhibitors have been developed for various clinical applications. We examined the effects of the Rho-kinase inhibitor Y27632 on keratinocyte proliferation and migration, and found that it promoted primary human keratinocyte proliferation and migration in both monolayer and skin explant cultures. In addition, topical application of Y27632 enhanced cutaneous wound closure in the majority of wounds in mice. The growth and migration effects of Y27632 appeared to be specific to keratinocytes compared with dermal fibroblasts, and required intact Jun kinase function. Y27632 seems to be a promising agent for keratinocyte procurement and wounding healing.

Full Text

Duke Authors

Cited Authors

  • Gandham, VD; Maddala, RL; Rao, V; Jin, JY; Epstein, DL; Hall, RP; Zhang, JY

Published Date

  • October 2013

Published In

Volume / Issue

  • 38 / 7

Start / End Page

  • 782 - 786

PubMed ID

  • 23675999

Pubmed Central ID

  • PMC3748215

Electronic International Standard Serial Number (EISSN)

  • 1365-2230

Digital Object Identifier (DOI)

  • 10.1111/ced.12067


  • eng

Conference Location

  • England