Plasmonic nanoprobes for intracellular sensing and imaging.

Journal Article (Review;Journal Article)

Recent advances in integrating nanotechnology and optical microscopy offer great potential in intracellular applications with improved molecular information and higher resolution. Continuous efforts in designing nanoparticles with strong and tunable plasmon resonance have led to new developments in biosensing and bioimaging, using surface-enhanced Raman scattering and two-photon photoluminescence. We provide an overview of the nanoprobe design updates, such as controlling the nanoparticle shape for optimal plasmon peak position; optical sensing and imaging strategies for intracellular nanoparticle detection; and addressing practical challenges in cellular applications of nanoprobes, including the use of targeting agents and control of nanoparticle aggregation.

Full Text

Duke Authors

Cited Authors

  • Yuan, H; Register, JK; Wang, H-N; Fales, AM; Liu, Y; Vo-Dinh, T

Published Date

  • July 2013

Published In

Volume / Issue

  • 405 / 19

Start / End Page

  • 6165 - 6180

PubMed ID

  • 23665636

Electronic International Standard Serial Number (EISSN)

  • 1618-2650

International Standard Serial Number (ISSN)

  • 1618-2642

Digital Object Identifier (DOI)

  • 10.1007/s00216-013-6975-1


  • eng