Feasibility of non-invasive determination of the stability of propagation reserve in patients

Journal Article

This study investigates the feasibility of using surface ECG recordings to assess stability of cardiac propagation. Our novel method customizes a reaction-diffusion model of cardiac excitation using measurements of patient's repolarization dynamics. The customized model determines the stability-of-propagation reserve (SoPR) that measures the proximity of the patient's minimum level of refractoriness to the critical level associated with conduction instability. Using measurements from 15 patients, we compared SoPRs determined from the unipolar intracardiac electrograms and from the surface ECG leads. SoPRs computed from intracardiac and surface measurements correlated, and a formula was developed that estimated the intracardiac SoPR from surface measurements with 5% accuracy. Thus, this study may lead to new noninvasive tests for the risk of sudden cardiac death. © 2012 CCAL.

Duke Authors

Cited Authors

  • Idriss, SF; Krassowska Neu, W; Varadarajan, V; Antonijevic, T; Gilani, SS; Starobin, JM

Published Date

  • December 1, 2012

Published In

Volume / Issue

  • 39 /

Start / End Page

  • 353 - 356

Electronic International Standard Serial Number (EISSN)

  • 2325-887X

International Standard Serial Number (ISSN)

  • 2325-8861

Citation Source

  • Scopus