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Multidisciplinary management of locally advanced rectal cancer: neoadjuvant approaches.

Publication ,  Journal Article
Murugappan, S; Harris, WP; Willett, CG; Lin, E
Published in: J Natl Compr Canc Netw
May 1, 2013

Although tumor biology and genomics of colon and rectal cancer are no different, patients with locally advanced rectal cancer (LARC) require neoadjuvant fluoropyrimidine-based chemoradiation and total mesorectal excision. In addition to known clinical risk factors, improved algorithms integrating molecular tools are needed to stratify patients with LARC to improve treatment outcomes and reduce acute and long-term toxicities. Simply combining newer systemic or targeted agents with standard treatment in all patients yielded little success but added toxicities. This article reviews the historical data, current standards of care, and ongoing research efforts regarding biomarkers, molecular imaging, and personalized genomic information.

Duke Scholars

Published In

J Natl Compr Canc Netw

DOI

EISSN

1540-1413

Publication Date

May 1, 2013

Volume

11

Issue

5

Start / End Page

548 / 557

Location

United States

Related Subject Headings

  • Rectal Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Neoadjuvant Therapy
  • Humans
  • Combined Modality Therapy
  • 4203 Health services and systems
  • 3211 Oncology and carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Murugappan, S., Harris, W. P., Willett, C. G., & Lin, E. (2013). Multidisciplinary management of locally advanced rectal cancer: neoadjuvant approaches. J Natl Compr Canc Netw, 11(5), 548–557. https://doi.org/10.6004/jnccn.2013.0071
Murugappan, Swaminathan, William P. Harris, Christopher G. Willett, and Edward Lin. “Multidisciplinary management of locally advanced rectal cancer: neoadjuvant approaches.J Natl Compr Canc Netw 11, no. 5 (May 1, 2013): 548–57. https://doi.org/10.6004/jnccn.2013.0071.
Murugappan S, Harris WP, Willett CG, Lin E. Multidisciplinary management of locally advanced rectal cancer: neoadjuvant approaches. J Natl Compr Canc Netw. 2013 May 1;11(5):548–57.
Murugappan, Swaminathan, et al. “Multidisciplinary management of locally advanced rectal cancer: neoadjuvant approaches.J Natl Compr Canc Netw, vol. 11, no. 5, May 2013, pp. 548–57. Pubmed, doi:10.6004/jnccn.2013.0071.
Murugappan S, Harris WP, Willett CG, Lin E. Multidisciplinary management of locally advanced rectal cancer: neoadjuvant approaches. J Natl Compr Canc Netw. 2013 May 1;11(5):548–557.

Published In

J Natl Compr Canc Netw

DOI

EISSN

1540-1413

Publication Date

May 1, 2013

Volume

11

Issue

5

Start / End Page

548 / 557

Location

United States

Related Subject Headings

  • Rectal Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Neoadjuvant Therapy
  • Humans
  • Combined Modality Therapy
  • 4203 Health services and systems
  • 3211 Oncology and carcinogenesis