Releasing the block: setting differentiation free with mutant IDH inhibitors.
Journal Article (Journal Article)
Hotspot mutations in IDH1 and IDH2 cause a differentiation block that can promote tumorigenesis. Two recent papers reported that small molecules targeting mutant IDH1 or mutant IDH2 release this differentiation block and/or impede tumor growth, providing a proof-of-concept that mutant IDHs are therapeutically targetable and that their effects are reversible.
Full Text
Duke Authors
Cited Authors
- Pirozzi, CJ; Reitman, ZJ; Yan, H
Published Date
- May 13, 2013
Published In
Volume / Issue
- 23 / 5
Start / End Page
- 570 - 572
PubMed ID
- 23680144
Pubmed Central ID
- 23680144
Electronic International Standard Serial Number (EISSN)
- 1878-3686
Digital Object Identifier (DOI)
- 10.1016/j.ccr.2013.04.024
Language
- eng
Conference Location
- United States