Releasing the block: setting differentiation free with mutant IDH inhibitors.

Journal Article (Journal Article)

Hotspot mutations in IDH1 and IDH2 cause a differentiation block that can promote tumorigenesis. Two recent papers reported that small molecules targeting mutant IDH1 or mutant IDH2 release this differentiation block and/or impede tumor growth, providing a proof-of-concept that mutant IDHs are therapeutically targetable and that their effects are reversible.

Full Text

Duke Authors

Cited Authors

  • Pirozzi, CJ; Reitman, ZJ; Yan, H

Published Date

  • May 13, 2013

Published In

Volume / Issue

  • 23 / 5

Start / End Page

  • 570 - 572

PubMed ID

  • 23680144

Pubmed Central ID

  • PMC4465106

Electronic International Standard Serial Number (EISSN)

  • 1878-3686

Digital Object Identifier (DOI)

  • 10.1016/j.ccr.2013.04.024


  • eng

Conference Location

  • United States