Releasing the block: setting differentiation free with mutant IDH inhibitors.
Hotspot mutations in IDH1 and IDH2 cause a differentiation block that can promote tumorigenesis. Two recent papers reported that small molecules targeting mutant IDH1 or mutant IDH2 release this differentiation block and/or impede tumor growth, providing a proof-of-concept that mutant IDHs are therapeutically targetable and that their effects are reversible.
Pirozzi, CJ; Reitman, ZJ; Yan, H
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