Synthesis of β2 -AR agonist BI-167107
Publication
, Journal Article
Wang, J; Seungkirl, A; Kahsai, AW; Liu, R; Ren, J; Hu, K; Sun, X; Chen, X
Published in: Chinese Journal of Organic Chemistry
March 1, 2013
BI-167107 is a new long-acting β2-adrenergic receptor (β2-AR) agonist, and has important application in determining the critical structures of receptor/ligand proteins complex of G-protein-coupled receptor (GPCR). By employing 2-nitroresorcinol as starting material, a practical synthetic route for BI-167107 has been developed, involving 7-step reactions. The structure of the target molecule has been confirmed by 1H NMR, 13C NMR and MS techniques. The advantages of the synthetic route include avoiding use of toxic reagents and being suitable for scale up preparation of BI-167107 and other benzoxazine derivatives. © 2013 Chinese Chemical Society and SIOC, CAS.
Duke Scholars
Published In
Chinese Journal of Organic Chemistry
DOI
ISSN
0253-2786
Publication Date
March 1, 2013
Volume
33
Issue
3
Start / End Page
634 / 639
Related Subject Headings
- Organic Chemistry
- 3405 Organic chemistry
Citation
APA
Chicago
ICMJE
MLA
NLM
Wang, J., Seungkirl, A., Kahsai, A. W., Liu, R., Ren, J., Hu, K., … Chen, X. (2013). Synthesis of β2 -AR agonist BI-167107. Chinese Journal of Organic Chemistry, 33(3), 634–639. https://doi.org/10.6023/cjoc201211015
Wang, J., A. Seungkirl, A. W. Kahsai, R. Liu, J. Ren, K. Hu, X. Sun, and X. Chen. “Synthesis of β2 -AR agonist BI-167107.” Chinese Journal of Organic Chemistry 33, no. 3 (March 1, 2013): 634–39. https://doi.org/10.6023/cjoc201211015.
Wang J, Seungkirl A, Kahsai AW, Liu R, Ren J, Hu K, et al. Synthesis of β2 -AR agonist BI-167107. Chinese Journal of Organic Chemistry. 2013 Mar 1;33(3):634–9.
Wang, J., et al. “Synthesis of β2 -AR agonist BI-167107.” Chinese Journal of Organic Chemistry, vol. 33, no. 3, Mar. 2013, pp. 634–39. Scopus, doi:10.6023/cjoc201211015.
Wang J, Seungkirl A, Kahsai AW, Liu R, Ren J, Hu K, Sun X, Chen X. Synthesis of β2 -AR agonist BI-167107. Chinese Journal of Organic Chemistry. 2013 Mar 1;33(3):634–639.
Published In
Chinese Journal of Organic Chemistry
DOI
ISSN
0253-2786
Publication Date
March 1, 2013
Volume
33
Issue
3
Start / End Page
634 / 639
Related Subject Headings
- Organic Chemistry
- 3405 Organic chemistry