Synthesis of β2-AR agonist BI-167107


Journal Article

BI-167107 is a new long-acting β2-adrenergic receptor (β2-AR) agonist, and has important application in determining the critical structures of receptor/ligand proteins complex of G-protein-coupled receptor (GPCR). By employing 2-nitroresorcinol as starting material, a practical synthetic route for BI-167107 has been developed, involving 7-step reactions. The structure of the target molecule has been confirmed by 1H NMR, 13C NMR and MS techniques. The advantages of the synthetic route include avoiding use of toxic reagents and being suitable for scale up preparation of BI-167107 and other benzoxazine derivatives. © 2013 Chinese Chemical Society and SIOC, CAS.

Full Text

Duke Authors

Cited Authors

  • Wang, J; Seungkirl, A; Kahsai, AW; Liu, R; Ren, J; Hu, K; Sun, X; Chen, X

Published Date

  • March 1, 2013

Published In

Volume / Issue

  • 33 / 3

Start / End Page

  • 634 - 639

International Standard Serial Number (ISSN)

  • 0253-2786

Digital Object Identifier (DOI)

  • 10.6023/cjoc201211015

Citation Source

  • Scopus