Deficiency in SLC25A1, encoding the mitochondrial citrate carrier, causes combined D-2- and L-2-hydroxyglutaric aciduria.

Journal Article (Journal Article)

The Krebs cycle is of fundamental importance for the generation of the energetic and molecular needs of both prokaryotic and eukaryotic cells. Both enantiomers of metabolite 2-hydroxyglutarate are directly linked to this pivotal biochemical pathway and are found elevated not only in several cancers, but also in different variants of the neurometabolic disease 2-hydroxyglutaric aciduria. Recently we showed that cancer-associated IDH2 germline mutations cause one variant of 2-hydroxyglutaric aciduria. Complementary to these findings, we now report recessive mutations in SLC25A1, the mitochondrial citrate carrier, in 12 out of 12 individuals with combined D-2- and L-2-hydroxyglutaric aciduria. Impaired mitochondrial citrate efflux, demonstrated by stable isotope labeling experiments and the absence of SLC25A1 in fibroblasts harboring certain mutations, suggest that SLC25A1 deficiency is pathogenic. Our results identify defects in SLC25A1 as a cause of combined D-2- and L-2-hydroxyglutaric aciduria.

Full Text

Duke Authors

Cited Authors

  • Nota, B; Struys, EA; Pop, A; Jansen, EE; Fernandez Ojeda, MR; Kanhai, WA; Kranendijk, M; van Dooren, SJM; Bevova, MR; Sistermans, EA; Nieuwint, AWM; Barth, M; Ben-Omran, T; Hoffmann, GF; de Lonlay, P; McDonald, MT; Meberg, A; Muntau, AC; Nuoffer, J-M; Parini, R; Read, M-H; Renneberg, A; Santer, R; Strahleck, T; van Schaftingen, E; van der Knaap, MS; Jakobs, C; Salomons, GS

Published Date

  • April 4, 2013

Published In

Volume / Issue

  • 92 / 4

Start / End Page

  • 627 - 631

PubMed ID

  • 23561848

Pubmed Central ID

  • PMC3617390

Electronic International Standard Serial Number (EISSN)

  • 1537-6605

Digital Object Identifier (DOI)

  • 10.1016/j.ajhg.2013.03.009


  • eng

Conference Location

  • United States