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Cigarette smoking and clopidogrel interaction.

Publication ,  Journal Article
Swiger, KJ; Yousuf, O; Bliden, KP; Tantry, US; Gurbel, PA
Published in: Curr Cardiol Rep
May 2013

Dual antiplatelet therapy (DAPT) with aspirin and an adenosine diphosphate receptor antagonist is central to the modern management of acute coronary syndromes and percutaneous revascularization. The most widely used adenosine diphosphate receptor antagonist, clopidogrel therapy is limited by inter-individual variability in platelet inhibition. Recent data suggest a potential role of smoking in the metabolism of clopidogrel and high on-treatment platelet reactivity. Pharmacodynamic studies and post-hoc analyses of large clinical trials support a link between smoking status and the efficacy of clopidogrel therapy. The mechanism of the interaction between smoking status and clopidogrel efficacy remains unclear but may be mediated by cytochrome P450 (CYP)1A2. There is less evidence available on the influence of smoking status on platelet reactivity and clinical outcomes during prasugrel and ticagrelor therapy.

Duke Scholars

Published In

Curr Cardiol Rep

DOI

EISSN

1534-3170

Publication Date

May 2013

Volume

15

Issue

5

Start / End Page

361

Location

United States

Related Subject Headings

  • Ticlopidine
  • Smoking Cessation
  • Smoking
  • Purinergic P2Y Receptor Antagonists
  • Platelet Aggregation Inhibitors
  • Humans
  • Clopidogrel
  • Cardiovascular System & Hematology
  • Blood Platelets
  • Acute Coronary Syndrome
 

Citation

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Swiger, K. J., Yousuf, O., Bliden, K. P., Tantry, U. S., & Gurbel, P. A. (2013). Cigarette smoking and clopidogrel interaction. Curr Cardiol Rep, 15(5), 361. https://doi.org/10.1007/s11886-013-0361-7
Swiger, Kristopher J., Omair Yousuf, Kevin P. Bliden, Udaya S. Tantry, and Paul A. Gurbel. “Cigarette smoking and clopidogrel interaction.Curr Cardiol Rep 15, no. 5 (May 2013): 361. https://doi.org/10.1007/s11886-013-0361-7.
Swiger KJ, Yousuf O, Bliden KP, Tantry US, Gurbel PA. Cigarette smoking and clopidogrel interaction. Curr Cardiol Rep. 2013 May;15(5):361.
Swiger, Kristopher J., et al. “Cigarette smoking and clopidogrel interaction.Curr Cardiol Rep, vol. 15, no. 5, May 2013, p. 361. Pubmed, doi:10.1007/s11886-013-0361-7.
Swiger KJ, Yousuf O, Bliden KP, Tantry US, Gurbel PA. Cigarette smoking and clopidogrel interaction. Curr Cardiol Rep. 2013 May;15(5):361.
Journal cover image

Published In

Curr Cardiol Rep

DOI

EISSN

1534-3170

Publication Date

May 2013

Volume

15

Issue

5

Start / End Page

361

Location

United States

Related Subject Headings

  • Ticlopidine
  • Smoking Cessation
  • Smoking
  • Purinergic P2Y Receptor Antagonists
  • Platelet Aggregation Inhibitors
  • Humans
  • Clopidogrel
  • Cardiovascular System & Hematology
  • Blood Platelets
  • Acute Coronary Syndrome