Antiplatelet therapy beyond 2012: role of personalized medicine.

Published

Journal Article (Review)

Since its first approval in 1997, clopidogrel has revolutionized interventional cardiology and transformed therapy for non‑ST‑segment elevation myocardial infarction (NSTEMI), STEMI, and percutaneous coronary intervention‑treated patients. It enjoyed a remarkable 15‑year "homerun" in the world market without any major competition. With the introduction of more potent P2Y12 receptor blockers, the current antiplatelet strategy is undergoing a transition period. Generic clopidogrel is inexpensive and pharmacodynamically effective in at least two thirds of the patients with coronary artery disease. The unpredictable, slow onset, and overall modest pharmacodynamic effects are the major limitations of clopidogrel. The new, more potent P2Y12 receptor blockers overcome the limitations of clopidogrel therapy and are associated with better clinical efficacy, but are more costly and associated with more bleeding. In this scenario, personalization of antiplatelet therapy based on platelet function and genetic testings to strike a balance between cost, benefit, and safety is a potential option.

Full Text

Duke Authors

Cited Authors

  • Tantry, US; Budaj, A; Gurbel, PA

Published Date

  • January 2012

Published In

Volume / Issue

  • 122 / 6

Start / End Page

  • 298 - 305

PubMed ID

  • 22751292

Pubmed Central ID

  • 22751292

Electronic International Standard Serial Number (EISSN)

  • 1897-9483

International Standard Serial Number (ISSN)

  • 1897-9483

Language

  • eng