Effect of long-term clopidogrel treatment on platelet function and inflammation in patients undergoing coronary arterial stenting.


Journal Article

A clopidogrel loading dose administered during stenting attenuates inflammation marker release. However, less is known of the anti-inflammatory effect of clopidogrel maintenance therapy. Platelet reactivity to adenosine diphosphate and inflammation markers were measured in 110 consecutive patients (69 clopidogrel-naive patients and 41 patients receiving long-term clopidogrel therapy for >6 months) before nonemergent stenting by turbidimetric aggregometry and flow cytometry and multianalyte profiling, respectively. All patients were treated with aspirin. Prestenting adenosine diphosphate-induced platelet aggregation, P-selectin, and activated glycoprotein IIb/IIIa expression were lower in patients receiving long-term clopidogrel therapy compared with the clopidogrel-naive group (p <0.001), accompanied by lower levels of selected inflammation markers (p < or = 0.05). Additionally, there were strong correlations between platelet aggregation and flow cytometric measurements (p < or = 0.04) and between specific inflammation markers (p < or = 0.02). In conclusion, in addition to markedly lowering platelet reactivity to adenosine diphosphate, long-term clopidogrel therapy is associated with an anti-inflammatory effect.

Full Text

Duke Authors

Cited Authors

  • Antonino, MJ; Mahla, E; Bliden, KP; Tantry, US; Gurbel, PA

Published Date

  • June 1, 2009

Published In

Volume / Issue

  • 103 / 11

Start / End Page

  • 1546 - 1550

PubMed ID

  • 19463513

Pubmed Central ID

  • 19463513

Electronic International Standard Serial Number (EISSN)

  • 1879-1913

Digital Object Identifier (DOI)

  • 10.1016/j.amjcard.2009.01.367


  • eng

Conference Location

  • United States