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AZD6140.

Publication ,  Journal Article
Tantry, US; Bliden, KP; Gurbel, PA
Published in: Expert Opin Investig Drugs
February 2007

Oral antiplatelet therapy with P2Y(12) receptor blockers (especially clopidogrel) is the current choice of treatment during acute coronary syndromes and percutaneous interventions. To address the various limitations of thienopyridine therapy (including response variability and non-responsiveness) a novel drug, AZD6140, is under clinical development. AZD6140 is an oral and reversible P2Y(12) receptor blocker that does not require hepatic conversion to an active metabolite and produces an overall superior ADP-induced platelet inhibition with less response variability than clopidogrel. It has fast onset and offset actions that may be advantageous in patients who may have to undergo immediate surgery.

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Published In

Expert Opin Investig Drugs

DOI

EISSN

1744-7658

Publication Date

February 2007

Volume

16

Issue

2

Start / End Page

225 / 229

Location

England

Related Subject Headings

  • Ticagrelor
  • Purinergic P2 Receptor Antagonists
  • Platelet Aggregation Inhibitors
  • Pharmacology & Pharmacy
  • Humans
  • Drugs, Investigational
  • Coronary Disease
  • Animals
  • Adenosine
  • 3214 Pharmacology and pharmaceutical sciences
 

Citation

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Tantry, U. S., Bliden, K. P., & Gurbel, P. A. (2007). AZD6140. Expert Opin Investig Drugs, 16(2), 225–229. https://doi.org/10.1517/13543784.16.2.225
Tantry, Udaya S., Kevin P. Bliden, and Paul A. Gurbel. “AZD6140.Expert Opin Investig Drugs 16, no. 2 (February 2007): 225–29. https://doi.org/10.1517/13543784.16.2.225.
Tantry US, Bliden KP, Gurbel PA. AZD6140. Expert Opin Investig Drugs. 2007 Feb;16(2):225–9.
Tantry, Udaya S., et al. “AZD6140.Expert Opin Investig Drugs, vol. 16, no. 2, Feb. 2007, pp. 225–29. Pubmed, doi:10.1517/13543784.16.2.225.
Tantry US, Bliden KP, Gurbel PA. AZD6140. Expert Opin Investig Drugs. 2007 Feb;16(2):225–229.

Published In

Expert Opin Investig Drugs

DOI

EISSN

1744-7658

Publication Date

February 2007

Volume

16

Issue

2

Start / End Page

225 / 229

Location

England

Related Subject Headings

  • Ticagrelor
  • Purinergic P2 Receptor Antagonists
  • Platelet Aggregation Inhibitors
  • Pharmacology & Pharmacy
  • Humans
  • Drugs, Investigational
  • Coronary Disease
  • Animals
  • Adenosine
  • 3214 Pharmacology and pharmaceutical sciences