Clinical applications of antiplatelet therapy.


Journal Article (Review)

Dual antiplatelet therapy with aspirin and a thienopyridine has become the standard of care for patients undergoing percutaneous intervention with stenting, regardless of indication. This article will examine the evidence for and against the use of aspirin and thienopyridines, with emphasis on platelet resistance and nonresponsiveness. Data suggest that in some patients, clopidogrel plus aspirin is not superior to aspirin alone. Resistance to aspirin and clopidogrel has been reported. Patients exhibiting aspirin resistance, as measured by an elevated platelet aggregate ratio, have a 10-fold increase in the risk of recurrent vascular events as compared to aspirin-sensitive patients. Clopidogrel nonresponsiveness has been a consistently observed phenomenon in studies utilizing various P2Y12 receptor-specific assays. Nonresponsiveness to clopidogrel treatment has been suggested as a risk factor for the occurrence of ischemic events and stent thrombosis.

Full Text

Duke Authors

Cited Authors

  • Wiviott, SD; Tantry, US; Gurbel, PA; American College of Cardiology, ; American Heart Association,

Published Date

  • 2006

Published In

Volume / Issue

  • 7 / 3

Start / End Page

  • 130 - 146

PubMed ID

  • 17088858

Pubmed Central ID

  • 17088858

International Standard Serial Number (ISSN)

  • 1530-6550


  • eng

Conference Location

  • United States