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Antiplatelet drug resistance and drug-drug interactions: Role of cytochrome P450 3A4.

Publication ,  Journal Article
Lau, WC; Gurbel, PA
Published in: Pharm Res
December 2006

Antiplatelet therapy provided pivotal advances in the treatment of cardiovascular disease. Aspirin and thienopyridine, clopidogrel, is currently the treatment of choice in acute coronary syndromes and the prevention of thrombosis after coronary stent implantation. Despite the efficacy of this dual antiplatelet therapy in reduction of adverse coronary events in patients with acute coronary syndromes, complications persist in a subgroup of these patients. Emerging causes of aspirin and clopidogrel resistance may translate to increase risk for recurrent myocardial infarction, stroke, or cardiac related mortality. However, the mechanism of antiplatelet drug resistance remains incompletely characterized, and a sensitive and specific assay of aspirin and clopidogrel effect that reliably predicts treatment failure has not emerged. To date, evidence supporting antiplatelet drug resistance are pharmacokinetic response variability, drug-drug interaction through competitive inhibition a specific enzymatic pathway, genetic variability, and variability in the induction of enzymatic pathway in metabolic activation of prodrugs, like clopidogrel. Further investigation or guidelines are needed to optimize antiplatelet treatment strategies to identify and treat patients resistant to aspirin and/or clopidogrel.

Duke Scholars

Published In

Pharm Res

DOI

ISSN

0724-8741

Publication Date

December 2006

Volume

23

Issue

12

Start / End Page

2691 / 2708

Location

United States

Related Subject Headings

  • Ticlopidine
  • Platelet Aggregation Inhibitors
  • Pharmacology & Pharmacy
  • Humans
  • Drug Resistance
  • Drug Interactions
  • Clopidogrel
  • Aspirin
  • Aryl Hydrocarbon Hydroxylases
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lau, W. C., & Gurbel, P. A. (2006). Antiplatelet drug resistance and drug-drug interactions: Role of cytochrome P450 3A4. Pharm Res, 23(12), 2691–2708. https://doi.org/10.1007/s11095-006-9084-4
Lau, Wei C., and Paul A. Gurbel. “Antiplatelet drug resistance and drug-drug interactions: Role of cytochrome P450 3A4.Pharm Res 23, no. 12 (December 2006): 2691–2708. https://doi.org/10.1007/s11095-006-9084-4.
Lau WC, Gurbel PA. Antiplatelet drug resistance and drug-drug interactions: Role of cytochrome P450 3A4. Pharm Res. 2006 Dec;23(12):2691–708.
Lau, Wei C., and Paul A. Gurbel. “Antiplatelet drug resistance and drug-drug interactions: Role of cytochrome P450 3A4.Pharm Res, vol. 23, no. 12, Dec. 2006, pp. 2691–708. Pubmed, doi:10.1007/s11095-006-9084-4.
Lau WC, Gurbel PA. Antiplatelet drug resistance and drug-drug interactions: Role of cytochrome P450 3A4. Pharm Res. 2006 Dec;23(12):2691–2708.
Journal cover image

Published In

Pharm Res

DOI

ISSN

0724-8741

Publication Date

December 2006

Volume

23

Issue

12

Start / End Page

2691 / 2708

Location

United States

Related Subject Headings

  • Ticlopidine
  • Platelet Aggregation Inhibitors
  • Pharmacology & Pharmacy
  • Humans
  • Drug Resistance
  • Drug Interactions
  • Clopidogrel
  • Aspirin
  • Aryl Hydrocarbon Hydroxylases
  • Animals