Skip to main content
Journal cover image

Platelet activation in myocardial ischemic syndromes.

Publication ,  Journal Article
Gurbel, PA; Bliden, KP; Hayes, KM; Tantry, U
Published in: Expert Rev Cardiovasc Ther
July 2004

Platelets play a central role in the pathogenesis of atherosclerosis and thrombosis. Platelet adhesion and aggregate formation are critical events that occur in unstable coronary syndromes. Platelet activation precedes the formation of homotypic and heterotypic aggregates. In the last 10 years, researchers have described the presence of activated platelets in the systemic circulation in various cardiovascular disease states, particularly acute coronary syndromes. This review describes the evidence for platelet activation in acute myocardial ischemic syndromes, describes the pathophysiology responsible for its occurrence, and discusses how platelet activation and reactivity may affect the use of concomitant drug therapies and patient prognosis.

Duke Scholars

Published In

Expert Rev Cardiovasc Ther

DOI

EISSN

1744-8344

Publication Date

July 2004

Volume

2

Issue

4

Start / End Page

535 / 545

Location

England

Related Subject Headings

  • Treatment Outcome
  • Syndrome
  • Platelet Membrane Glycoproteins
  • Platelet Activation
  • Myocardial Ischemia
  • Humans
  • Fibrinolytic Agents
  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology
  • 1117 Public Health and Health Services
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gurbel, P. A., Bliden, K. P., Hayes, K. M., & Tantry, U. (2004). Platelet activation in myocardial ischemic syndromes. Expert Rev Cardiovasc Ther, 2(4), 535–545. https://doi.org/10.1586/14779072.2.4.535
Gurbel, Paul A., Kevin P. Bliden, Kevin M. Hayes, and Udaya Tantry. “Platelet activation in myocardial ischemic syndromes.Expert Rev Cardiovasc Ther 2, no. 4 (July 2004): 535–45. https://doi.org/10.1586/14779072.2.4.535.
Gurbel PA, Bliden KP, Hayes KM, Tantry U. Platelet activation in myocardial ischemic syndromes. Expert Rev Cardiovasc Ther. 2004 Jul;2(4):535–45.
Gurbel, Paul A., et al. “Platelet activation in myocardial ischemic syndromes.Expert Rev Cardiovasc Ther, vol. 2, no. 4, July 2004, pp. 535–45. Pubmed, doi:10.1586/14779072.2.4.535.
Gurbel PA, Bliden KP, Hayes KM, Tantry U. Platelet activation in myocardial ischemic syndromes. Expert Rev Cardiovasc Ther. 2004 Jul;2(4):535–545.
Journal cover image

Published In

Expert Rev Cardiovasc Ther

DOI

EISSN

1744-8344

Publication Date

July 2004

Volume

2

Issue

4

Start / End Page

535 / 545

Location

England

Related Subject Headings

  • Treatment Outcome
  • Syndrome
  • Platelet Membrane Glycoproteins
  • Platelet Activation
  • Myocardial Ischemia
  • Humans
  • Fibrinolytic Agents
  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology
  • 1117 Public Health and Health Services