The role of platelet receptors and adhesion molecules in coronary artery disease.

Journal Article (Journal Article;Review)

Platelets play a significant role in coronary artery disease through interactions with each other and with other cell types. These interactions are mediated by certain receptors on the surface of platelets and other cells which can lead to intra-coronary thrombus formation and occlusion that may result in acute coronary syndromes. The important roles of the currently available anti-platelet therapies have been well established in many clinical outcome trials in cardiovascular patients. An understanding of these different interactions provides the clinician with a background that supports the clinical importance of currently available anti-platelet therapies. Moreover, knowledge of the mechanisms of cellular crosstalk will lead to important advances in the development of better antithrombotic therapies.

Full Text

Duke Authors

Cited Authors

  • Samara, WM; Gurbel, PA

Published Date

  • February 2003

Published In

Volume / Issue

  • 14 / 1

Start / End Page

  • 65 - 79

PubMed ID

  • 12629328

International Standard Serial Number (ISSN)

  • 0954-6928

Digital Object Identifier (DOI)

  • 10.1097/00019501-200302000-00008


  • eng

Conference Location

  • England