Baseline platelet aggregation and major receptor expression predict subsequent activity following thrombolysis for acute myocardial infarction.

Journal Article (Clinical Trial;Clinical Trial, Phase III;Journal Article)

The early identification of patients with heightened platelet activity for aggressive antiplatelet regimens represents a critical clinical issue in acute myocardial infarction (AMI) therapy. We sought to determine whether the degree of pre-reperfusion platelet function is related to subsequent activity following thrombolysis. Platelets were investigated at baseline and at 24 h following thrombolytic therapy by aggregometry, and flow cytometry in 19 AMI patients enrolled in the GUSTO-III trial. Regression analysis revealed a significant correlation for 5 microM ADP (r2 = 0.529), 10 microM ADP (r2 = 0.445), thrombin (r2 = 0.226), collagen (r2 = 0.568), and ristocetin-induced aggregation (r2 = 0.964). Platelet expression linearly correlated for GPIIb/IIIa (r2 = 0.337), P-selectin (r = 0.817), PECAM-1 (r2 = 0.586), and the vitronectin receptor (r2 = 0.634). The data suggest that the baseline characteristics predict future platelet activity, and may prospectively identify patients who will benefit most from antiplatelet strategies after coronary thrombolysis.

Full Text

Duke Authors

Cited Authors

  • Gurbel, PA; Kereiakes, DJ; Atar, D; Serebruany, VL

Published Date

  • 2000

Published In

Volume / Issue

  • 34 / 1

Start / End Page

  • 53 - 58

PubMed ID

  • 10816061

International Standard Serial Number (ISSN)

  • 1401-7431

Digital Object Identifier (DOI)

  • 10.1080/14017430050142404


  • eng

Conference Location

  • England