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Intracoronary magnesium and diltiazem affect to a similar extent certain hemostatic factors during acute myocardial infarction in swine.

Publication ,  Journal Article
Serebruany, VL; Schlossberg, ML; Edenbaum, LR; Herzog, WR; Gurbel, PA
Published in: Pharmacology
October 1996

The use of calcium antagonists and magnesium (Mg) in the treatment of acute myocardial infarction is controversial. We compared changes in hemostasis during acute myocardial infarction after either low-dose intracoronary Mg or diltiazem infusion in 20 Yorkshire swine undergoing thoracotomy and coronary artery occlusion for 50 min, followed by 3 h of reperfusion. The first group received MgSO4 (250 mg), delivered at the onset of reperfusion, the second group received diltiazem (2.5 mg) at the beginning of reperfusion. Six controls received saline. Plasma antithrombin III, protein C, total protein S, fibronectin, endothelin 1, and metabolites of thromboxane and prostacyclin were measured at baseline, twice during occlusion, and three times during reperfusion. Compared to controls, Mg and diltiazem infusion diminished endothelin 1 (32.9 vs. 34.5%) and fibronectin. (21.7 vs. 23.2%), but increased protein C (31.9 vs. 29.3%). Intracoronary Mg, like diltiazem, improved hemostasis in swine.

Duke Scholars

Published In

Pharmacology

DOI

ISSN

0031-7012

Publication Date

October 1996

Volume

53

Issue

4

Start / End Page

224 / 233

Location

Switzerland

Related Subject Headings

  • Swine
  • Protein S
  • Protein C
  • Pharmacology & Pharmacy
  • Myocardial Reperfusion Injury
  • Myocardial Infarction
  • Magnesium
  • Hemodynamics
  • Fibronectins
  • Female
 

Citation

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Serebruany, V. L., Schlossberg, M. L., Edenbaum, L. R., Herzog, W. R., & Gurbel, P. A. (1996). Intracoronary magnesium and diltiazem affect to a similar extent certain hemostatic factors during acute myocardial infarction in swine. Pharmacology, 53(4), 224–233. https://doi.org/10.1159/000139434
Serebruany, V. L., M. L. Schlossberg, L. R. Edenbaum, W. R. Herzog, and P. A. Gurbel. “Intracoronary magnesium and diltiazem affect to a similar extent certain hemostatic factors during acute myocardial infarction in swine.Pharmacology 53, no. 4 (October 1996): 224–33. https://doi.org/10.1159/000139434.
Serebruany VL, Schlossberg ML, Edenbaum LR, Herzog WR, Gurbel PA. Intracoronary magnesium and diltiazem affect to a similar extent certain hemostatic factors during acute myocardial infarction in swine. Pharmacology. 1996 Oct;53(4):224–33.
Serebruany, V. L., et al. “Intracoronary magnesium and diltiazem affect to a similar extent certain hemostatic factors during acute myocardial infarction in swine.Pharmacology, vol. 53, no. 4, Oct. 1996, pp. 224–33. Pubmed, doi:10.1159/000139434.
Serebruany VL, Schlossberg ML, Edenbaum LR, Herzog WR, Gurbel PA. Intracoronary magnesium and diltiazem affect to a similar extent certain hemostatic factors during acute myocardial infarction in swine. Pharmacology. 1996 Oct;53(4):224–233.
Journal cover image

Published In

Pharmacology

DOI

ISSN

0031-7012

Publication Date

October 1996

Volume

53

Issue

4

Start / End Page

224 / 233

Location

Switzerland

Related Subject Headings

  • Swine
  • Protein S
  • Protein C
  • Pharmacology & Pharmacy
  • Myocardial Reperfusion Injury
  • Myocardial Infarction
  • Magnesium
  • Hemodynamics
  • Fibronectins
  • Female