A canine model of acute coronary artery thrombosis for the evaluation of reperfusion strategies.


Journal Article

A model of coronary artery thrombosis which: (1) provides a stable thrombus; (2) incorporates intimal injury; (3) has a low mortality rate; (4) responds predictably to thrombolytic therapy, and (5) is technically simple, was developed. Intimal injury was produced proximal to a critical stenosis and followed by the infusion of a blood and thrombin mixture into the injured segment. After thrombus formation flow remained absent in all control animals (n = 7). Microscopy showed intimal injury and coronary thrombosis with platelets adherent to the subendothelium. In animals treated with tissue plasminogen activator (n = 7) flow returned to > 60% of baseline at 20.2 +/- 7.7 min and was cyclical. Mortality and complications were infrequent. This model is useful in investigations of reperfusion therapy.

Full Text

Duke Authors

Cited Authors

  • Gurbel, PA; MacCord, CS; Anderson, RD; Scott, H; Atar, D; Mergner, W; Herzog, WR

Published Date

  • 1994

Published In

Volume / Issue

  • 84 / 1

Start / End Page

  • 1 - 8

PubMed ID

  • 8149384

Pubmed Central ID

  • 8149384

International Standard Serial Number (ISSN)

  • 0008-6312

Digital Object Identifier (DOI)

  • 10.1159/000176322


  • eng

Conference Location

  • Switzerland