Effect of magnesium sulphate infusion on ex vivo platelet aggregation in swine.

Journal Article

The effect of magnesium sulphate infusion on ex vivo platelet aggregation in 11 female Yorkshire swine was observed using platelet-rich plasma and different agonists (ADP 5 mM; ADP 10 mM and collagen 1 mg/ml). Infusion of 1 g MgSO4 over 1 h produced a significant decrease in platelet aggregability. A dose-dependent effect of different ADP concentrations on platelet aggregation was noticed. Platelet inhibition was most consistent when using ADP 5 mM. We estimate this concentration of agonist as optimal in swine. The swine model is a good choice for investigation of in vivo platelet activation, especially with regard to cardiovascular research. We conclude that there is an inhibitory effect of supplemental magnesium on ex vivo platelet aggregation in swine with initial normomagnesaemia.

Full Text

Duke Authors

Cited Authors

  • Herzog, WR; Atar, D; Gurbel, PA; Vogel, RA; Schlossberg, ML; Serebruany, VL

Published Date

  • December 1993

Published In

Volume / Issue

  • 6 / 4

Start / End Page

  • 349 - 353

PubMed ID

  • 8155486

International Standard Serial Number (ISSN)

  • 0953-1424

Language

  • eng

Conference Location

  • England